Quest Diagnostics Investments, Inc.

Somalogic, Incorporated

Jennifer C Bertino

Weimin Sun

Charles M Strom

Chris Bock

Malti P Nikrad

Bharat Nathu Gawande

Deborah Ayers

Noh Jin Park

The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3' cap. In some embodiments, the 3&#x2032; cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5&#x2032;-end of the aptamer and the moiety is attached the 5&#x2032; end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.

Aptamers and diagnostic methods for detecting the EGF receptor

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Arvada, CO, United States of America

Jennifer C Bertino