Other

Oregon State University

Allvivo Vascular, Inc.

Allvivio Vascular, Inc.

Allvivo, Inc.

Jennifer A Neff

Danir F Bayramov

Karin Caldwell

Bo Nilsson

Pranav Ramchandra Joshi

Joseph McGuire

Jonas Andersson

Kristina Nilsson-Ekdahl

Wade Akira Takeguchi

Pranav R Joshi

Joseph Mcguire

Karin D Caldwell

The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC&#xae; F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.

Antimicrobial constructs

Coatings comprising protein resistant components and therapeutic components on medical devices are disclosed. The coatings act to down-regulate complement activation. Medical devices can be coated with these coatings to prevent side effects and improve patency.

Medical device with surface coating comprising bioactive compound

Elutable coatings comprising protein resistant components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved under controlled conditions.

Elutable surface coating

A method for coimmobilizing two or more biomolecules on a substrate in a defined ratio is disclosed. The method uses a copolymer conjugated to a number, N, of different types of oligonucleotides. The copolymer can be adsorbed to the surface of the substrate. N types of oligonucleotides complementary to the copolymer-bound oligonucleotides can be conjugated to N types of biomolecules. The types of the copolymer-bound oligonucleotides can be mixed in a defined ratio then adsorbed to the surface. The biomolecule-bound complementary oligonucletides can be conjugated to the copolymer-oligonucleotides to create a substrate with the biomolecules coimmobilized in a defined ratio. The invention also relates to a substrate prepared by the method of the invention.

End group activated polymers with oligonucleotide ligands

Surface coating comprising bioactive compound

Growing community of inventors

Rancho Santa Margarita, CA, United States of America

Jennifer A Neff