Other

California Institute of Technology

Materia, Inc.

Jennifer A Love

Robert H Grubbs

Tina M Trnka

Jason Lee Moore

Melanie S Sanford

Arnab Kumar Chatterjee

F Dean Toste

John P Morgan

Tae-Lim Choi

Daniel P Sanders

Matthias Scholl

Jason L Moore

Steven D Goldberg

The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.

Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts

Hexacoordinated ruthenium or osmium metal carbene metathesis catalysts

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Pasadena, CA, United States of America

Jennifer A Love