Denali Therapeutics Inc.

Jennifer A Getz

Mark S Dennis

Yin Sheng Zhang

Adam P Silverman

Joy Yu Zuchero

Rinkan Shukla

In one aspect, antibodies that specifically bind to a human BACE1 protein are provided herein. In some embodiments, the antibodies contain modifications that reduce effector function, extend serum stability or serum half-life, or promote heterodimerization. In other aspects, bispecific antibodies and pharmaceutical compositions comprising antibodies that bind to human BACE1 protein are provided herein. Methods for inhibiting amyloid-&#x3b2; formation and/or aggregation, inhibiting amyloid plaque formation, and treating neurodegenerative diseases are also provided herein.

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South San Francisco, CA, United States of America

Jennifer A Getz