Genentech, Inc.

Genetech, Inc.

F. Hoffmann-la Roche Ag

Jennie Lill

Ira Mellman

Mahesh Yadav

Lelia Delamarre

Suchit Jhunjhunwala

Richard L Vandlen

David P Arnott

Wendy N Sandoval

The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.

Identification of immunogenic mutant peptides using genomic, transcriptomic and proteomic information

Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry.

Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry

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Pacifica, CA, United States of America

Jennie Lill