Medtronic Minimed, Inc.

Ethicon, Gmbh

The University of Texas System

Minimed, Inc.

Jenn-Hann Larry Wang

Rajiv Shah

Paul Taylor Jacobs

Szu-Min Lin

Michael E Miller

Raghavendhar Gautham

Yiwen Li

Udo Hoss

John Joseph Mastrototaro

Poonam S Gulati

Richard B Timmons

Dero Hovanes

Ning Yang

Robert C Mucic

Bradley Chi Liang

Wayne A Morgan

Yanan Zhang

David J Vachon

Bradley J Enegren

Nannette M Van Antwerp

James P Kohler

Richard Jed Kendall

Brooks B Cochran

Catherine M Szyman

Paris Chen

Kent L Clark

Genival D De Barros

Carlos A Callirgos

Manjunath Sirigiri

Joseph Paul Brinson

Yunbing Wang

William P Van Antwerp

Ellis Garai

Harold R Williams

Peter C Zhu

Robert C Platt

Ashwin K Rao

Tri T Dang

Alfredo M Choperena

Robert Lukasik

Anahid Gamsarian

Yuliang Wu

Charles R Savage

Suz-Min Lin

John J Mastrototaro

A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Immunosuppressant releasing coatings

Embodiments of the invention provide compositions useful in analyte sensors as well as methods for making and using such compositions and sensors. In typical embodiments of the invention, the sensor is a glucose sensor comprising an analyte modulating membrane formed from a polymeric reaction mixture formed to include limiting amounts of catalyst and/or polycarbonate compounds so as to provide such membranes with improved material properties such as enhanced thermal and hydrolytic stability.

Thermally stable glucose limiting membrane for glucose sensors

Embodiments of the invention provide compositions useful in analyte sensors as well as methods for making and using such compositions and sensors. In typical embodiments of the invention, the sensor is a glucose sensor comprising an analyte modulating membrane formed from a polymer composition having carbonate and aromatic isocyanate chains, a composition observed to provide such membranes with improved material properties such as enhanced thermal and hydrolytic stability.

Polycarbonate urea/urethane polymers for use with analyte sensors

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.

Analyte sensors and methods for making and using them

Growing community of inventors

Northridge, CA, United States of America

Jenn-Hann Larry Wang