Academia Sinica

Synology Inc.

Jen-Yao Chang

Cheng-Han Lee

Jim-Min Fang

Chih-Cheng Chen

Zuo-Rong Yang

Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5'-glycylcarbonyl-N-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

Compound with analgesic effect for use in prevention and treatment of pain

Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5'-O-(glycine-N-carbonyl-N-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5-deoxy-5&#x2032;-(glycine-N-amido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

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Taipei, Taiwan

Jen-Yao Chang