Atomic Energy Council-institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Solteam Opto, Inc.

Jen-Tsung Wang

Wuu-Jyh Lin

Mei-Hui Wang

Yu Lung Chang

Cheng-Fang Hsu

Hung-Man Yu

Kun-Liang Lin

Chin-Feng Chen

Chih-Yuan Lin

Chuan-Yi Chien

Ping-Yen Wang

Yan-Feng Jiang

Rui-Yu Chen

Wei-Ti Kuo

Hung-Wen Yu

The present invention provides a method for preparing a 6-aminohexyl lactoside-NOTA conjugate. The preparation method comprises brominating perbenzoylated lactose with hydrobromic acid; glycosylating 6-azidohexanol to obtain 6-azidohexyl perbenzoyl lactoside; and deprotecting this precursor in two steps to obtain 6-aminohexyl lactoside and conjugating 6-aminohexyl lactoside to NCS-benzyl-NODA GA (i.e. 2,2'-(7-(1-carboxy-4-((4-isothiocyanate benzyl) amino)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl) diacetic acid) in triethyl amine as an alkaline solvent, to obtain a 6-aminohexyl lactoside-NCS-benzyl-NODA GA conjugate. In this novel preparation method, no deglycosylated side product is produced, such that the yield is considerably increased to 46%. Therefore, the method is suitable for future massive production since the requirement for repeated preparations for massive production is reduced, and the impurities produced in the previously scaled-up preparation process are not present.

Method for preparing 6-aminohexyl lactoside-NOTA conjugate

A novel gall bladder image agent which includes a radio-labelled MAG3-tri-galactosamine, and its preparation method, which includes reacting mercaptoacetyltriglycine (MAG3)-tri-galactosamine, SnF2 and Tc-99m in the presence of a phosphate buffer solution (at pH of from 10.0&#x2dc;12.0) to obtain Tc-99m-MAG3-tri-galactosamine, when the MAG3-tri-galactosamine is MAG3-DCM-Lys(Gah-GalNAc)3 (where DCM represents a dicarboxymethyl group, and Gah represents a glycine-aminohexyl group), it obtains a labelling yield of at least 90%, and its specific radioactivity is at least 7.0&#xd7;109 Bq/mg.

Gall bladder imaging agent and its preparation method

A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, N,N-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.

Method for preparing precursor used for labeling hepatocyte receptor and containing trisaccharide and DTPA ligand

A composite audio/video output connector comprises an insulating base, a first connecting port with a flat connecting surface and a second connecting port with a transversally extended inserting post disposed at and its upper and middle section of the base respectively, and the lower base includes a third connecting port comprising an optical fiber sheathing base, a one-way doorstop with a U-shape dual axial springs for embedding the optical fiber sheathing base into a base chamber at the lower section of the base; a front casing corresponding to each connecting port to form a slot and a folded edge formed on each of the four sides of a panel for connecting the front edge of the base; and a sealed cover having pin holes for extending the pins of a metal terminal and an optical element and engaging the sealed cover to an opening at the bottom of the base.

Composite audio/video output connector

Growing community of inventors

Taoyuan, Taiwan

Jen-Tsung Wang