National Health Research Institutes

Tsinghua University

National Defense Medical Center

Jen-Kun Chen

Chung-Shi Yang

Yeu-Kuang Hwu

Dueng-Yuan Hueng

Leu-Wei Lo

Yong-Chien Ling

Fong-In Chou

Wei-Neng Liao

Jinn-Jer Peir

Chia-Hung Lee

Fu-Der Mai

Fong-Sian Lin

Feng-Yin Li

Bega Liu

Mei-Hui Shih

Mo-Hsiung Yang

Chih-Hui Liu

Mei-Ya Wang

Shih-Hsun Cheng

Li-Hui Tsai

Hsin-Ying Clair Chiou

Teh-Min Hu

The present invention relates to complex particles for delivering nitric oxide, method of producing the particles, and application of the particles, and more particularly, relates to complex particles for delivering nitric oxide and an additional therapeutic reagent.

Complex particles for delivering nitric oxide, method of producing the same, and application of the same

A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Auions; c) suspending the amine-modified silica particle in the solution comprising Auions; d) allowing the Auions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Auions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).

Solid phase gold nanoparticle synthesis

Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing an aqueous composition comprising gold (Au-197) ions in the absence of a template; and b) exposing the aqueous composition in the absence of the template to neutron irradiation to generate the composition comprising the non-ionic R-GNPs. Alternatively, the method comprises: a) providing an aqueous composition comprising gold (Au-197) nanoparticles (GNPs) in the absence of a template; and b) exposing the aqueous composition comprising the GNPs in the absence of the template to neutron irradiation and thereby generating the composition comprising the non-ionic R-GNPs. Compositions that comprises mesoporous silica nanoparticles (MSNs) and non-ionic R-GNPs encapsulated within pores and/or channels and further anchored to the surfaces of the MSNs, and methods of making the same are also disclosed.

Radioactive gold nanoparticles and methods of making and using them

A nano-particle containing apparatus, a nano-particle detection system and a method are disclosed. The nano-particle containing apparatus includes a casing, an air extracting device, a pressure device and a measuring instrument. The casing has a containing space for disposing a plurality of nano-particles. An internal wall surface of the casing has active self-cleaning function. The pressure control device controls the pressure status of the containing space. The active self-clean function is that nano-particles adhered to the internal surface wall are removed into the containing space. The nano-particles then are pumped by the air extracting device from the containing space. The measuring instrument then detects the status of an object affected by the nano-particles after the object is delivered into the containing space.

Nano-particle containing apparatus, nano-particle detection system and method thereof

Growing community of inventors

Hsinchu, Taiwan

Jen-Kun Chen