University of Pennsylvania

Jen-Chih Hsieh

George Cotsarelis

Ying Zheng

David Collins

Joan O'Brien

David W Collins

DP-2 antagonists reversed PGD-mediated human hair growth inhibition in a dose-dependent manner in vitro by reducing PGD-triggered apoptosis and maintaining proliferation of keratinocytes. Hair follicles from approximately half of the alopecia patients exhibited little susceptibility to PGD's effect in vitro. SNPs in the human DP-2 gene were identified that are associated with hair growth inhibition by PGD. These findings underscore the role of DP-2 in regulating hair growth and indicate that DP-2 can be an effective approach in preventing and/or treating androgenetic alopecia in patients sensitive to PGD. Furthermore, the SNPs identified here can be used to identify patients who will benefit from treatment.

Single nucleotide polymorphic alleles of human DP-2 gene for detection of susceptibility to hair growth inhibition by PGD2

This invention is directed to compositions for promoting wound healing and regeneration and methods of use thereof. In one aspect, methods for promoting wound healing in a subject are provided, the methods comprising: administering a therapeutically effective amount of a DNA methyl transferase inhibitors (DNMT) to the subject. In another aspect, methods for reducing scarring during healing of a skin wound are provided, the methods comprising: administering a therapeutically effective amount of a DNMT inhibitor.

Growing community of inventors

South Setauket, NY, United States of America

Jen-Chih Hsieh