Dong Wha Pharmaceutical Co. Ltd.

Jei-Man Ryu

Jin-Soo Lee

Jin-soo Lee

Yun-Ha Hwang

Yong-Ho Chung

Eun-Joo Kim

Hong-Suk Suh

Pan-Soo Kim

Do-Hui Kim

Yong-Youp Park

This invention relates to a pharmaceutical composition containing 4-[(4-thiazolyl)phenoxyl]alkoxy-benzamidine derivatives expressed by the following formula 1 for the prevention and treatment of osteoporosis and more particularly, to the use of 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine or N-hydroxy-4-{5-[4-(5-iso-propyl-2-methyl-1,3-thiazol-4-yl)phenoxyl]pentoxy}-benzamidine expressed by the following formula 1, which is known as an antagonist of leukotriene-Breceptor, as a pharmaceutical composition for the prevention and treatment of osteoporosis. [Formula 1], wherein, R is a hydrogen atom or a hydroxy group.

Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis

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Anyang-si, South Korea

Jei-Man Ryu