Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Al-quds University

Jehoshua Katzhendler

Yechezkel Barenholz

Oren Tirosh

Ron Kohen

Yosefa Avraham

Dan Gibson

Elliot Berry

Yousef Najajreh

Raphael Mevorach

Ada Schlossman

Yousuf Najajreh

Meir Saidian

Provided are new fatty acid derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, e.g., as agents for the treatment of obesity and related disorders, and for improving cognition.

Compounds and methods of treating obesity

The present invention relates to novel types of peptide nucleic acids (PNAS) with improved properties. In particular, it relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising these units, and to the use of positively charged PNAs as novel delivery agents with therapeutic and diagnostic applications including for antisense therapy.

Positively-charged peptide nucleic acid analogs with improved properties

Ether-linked phospholipids, derivatized at the polar head group with polyethylene glycol chains having molecular weights greater than 2,000 daltons, are disclosed. Lipid bilayers containing these phospholipids show high oxidative stability. Also disclosed is the use of PEG-derivatized ether-linked lipids in moisturizing and radiation-protective cosmetic compositions.

Radiation-protective phospholipid and method

Growing community of inventors

Jerusalem, Israel

Jehoshua Katzhendler