Max-delbrueck-centrum Fuer Molekulare Medizin

Max-delbruck-centrum Fur Molekulare Medizin (mdc) Berlin-buch

Max-delbruck-centrum Fur Molekulare Medizin

Max-delbruck-centrum Fur Molekulare Medizin Berlin-buch

Jehad Charo

Thomas Blankenstein

Wolfgang Uckert

Elisa Kieback

Cynthia Perez

The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.

Epitope-tag surface expressed proteins and nucleic acids thereof

The present invention relates generally to the field of molecular biology. More specifically, the present invention relates to expression systems for use in modulating the expression of protein coding target genes in vivo or in vitro. More specific, this invention relates to RNA polymerase III-based methods and systems for expression of therapeutic proteins in cells in vivo or in vitro.

Use of Pol III promoters for controlled expression of therapeutic proteins

Growing community of inventors

Berlin, Germany

Jehad Charo