Twelve, Inc.

Xtent, Inc.

J.w. Medical Systems Ltd.

Foundry Innovation & Research 1, Ltd.

The Foundry, Inc.

Stanford Surgical Technologies, Inc.

Mitrx, Inc.

Jeffry J Grainger

Hanson S Gifford, Iii

Bernard H Andreas

John H Morriss

James I Fann

Mark E Deem

David W Snow

Darin Charles Gittings

Hanson Gifford

Michael Luna

Douglas Sutton

Jean-Pierre Dueri

Matt McLean

Conor M Hanley

Stephen Kao

Fiachra M Sweeney

John R Britton

Annette Kent

Hanson S Gifford

Albert K Chin

Timothy R Machold

Michael J Hendricksen

Douglas S Sutton

Alex T Roth

Wesley D Sterman

Denise M Demarais

Mark Y Hirotsuka

Philip Christopher Evard

Lawrence C Siegel

Joseph Karratt

Vijaykumar Rajasekhar

Murali Dharan

Iii Hanson S Gifford

Mark Deem

Hanson S Iii Gifford

Systems and methods are disclosed that provide for regular, periodic or continuous monitoring of fluid volume based on direct measurement of an inferior vena cava (IVC) physical dimension using a wireless measurement sensor implanted in the IVC. By basing diagnostic decisions and treatments on changes in an IVC physical dimension, information on patient fluid state is available across the entire euvolemic range of fluid states, thus providing earlier warning of hypervolemia or hypovolemia and enabling the modulation of patient treatments to permit more stable long-term fluid management.

Systems and methods for self-directed patient fluid management

Systems for mitral valve repair are disclosed where one or more mitral valve interventional devices may be advanced intravascularly into the heart of a patient and deployed upon or along the mitral valve to stabilize the valve leaflets. The interventional device may also facilitate the placement or anchoring of a prosthetic mitral valve implant. The interventional device may generally comprise a distal set of arms pivotably and/or rotating coupled to a proximal set of arms which are also pivotably and/or rotating coupled. The distal set of arms may be advanced past the catheter opening to a subannular position (e.g., below the mitral valve) and reconfigured from a low-profile delivery configuration to a deployed securement configuration. The proximal arm members may then be deployed such that the distal and proximal arm members may grip the leaflets between the two sets of arms to stabilize the leaflets.

System for mitral valve repair and replacement

Systems, devices, and methods for providing access to the heart. The system includes an intracardiac access device comprising an elongate member having a channel extending between a distal end and a proximal end thereof. The intracardiac access device is configured to be advanced through an extrapericardial penetration in the left atrial wall without penetrating the pericardium of the heart. An optional procedural device is configured to be advanced through the channel of the intracardiac access device into an internal chamber of the heart and configured to perform a surgical procedure in the internal chamber of the heart. A working channel of an optional suprasternal access device is configured to facilitate access of the intracardiac access device into the body of the patient by providing a path from a suprasternal opening to a position adjacent the roof of the left atrium.

Devices and methods for accessing the left atrium for cardiac procedures

Systems and methods for patient fluid management

Various devices, systems and methods for knotless suturing of tissue are disclosed. These devices allow sutures to be anchored to bone, and more specifically provide a suture anchor which eliminates the need for knotting the suture. Thus, damaged tissue may be re-attached to a substrate tissue. The anchors have a minimum of moving parts may be suited to being a single molded polymer construction. The anchors will find particular utility in hip and shoulder arthroscopy, e.g. labral re-attachment and similar procedures.

Knotless suture anchor and methods of use

Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.

Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods

Implantable devices for continuously monitoring vascular lumen dimensions, in particular in the inferior vena cava (IVC) for determining heart failure status of a patient. Related therapy systems as well as monitoring and therapy methods are also disclosed. Devices include active or passive marker elements placed in contact with, adhered to or injected into the vessel wall to generate or reflect signals from which lumen diameter may be determined. Disclosed devices may be fully implantable and self-contained including capabilities for wirelessly communication monitored parameters.

Implantable devices and related methods for heart failure monitoring

A prosthetic heart valve () includes a flexible anchoring member () at least partially surrounding and coupled to an inner valve support (). The device can further include a prosthetic valve () coupled to, mounted within, or otherwise carried by the valve support. The valve support includes a plurality of posts () connected circumferentially by a plurality of struts (), where the posts extend along an axial direction generally parallel to the longitudinal axis () and the struts extend circumferentially around and transverse to the longitudinal axis. The posts extend an entire longitudinal height HI of the valve support. The device also includes one or more sealing members () and tissue engaging elements () like spikes.

Prosthesis delivery devices and methods are provided that enable precise control of prosthesis position during deployment. The prosthesis delivery devices may carry multiple prostheses and include deployment mechanisms for delivery of a selectable number of prostheses. Control mechanisms are provided in the prosthesis delivery devices that control either or both of the axial and rotational positions of the prostheses during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries, or in other vascular locations.

Devices and methods for controlling expandable prostheses during deployment

Blood vessels and other body lumens are stented using stent structures comprising a plurality of radially expansible rings where at least some of the rings comprise axially extending elements which interleave with axially extending elements on adjacent unconnected rings. The ring structures may be open cell structures or closed cell structures, and the axially extending elements will typically be formed as part of the open cell or closed cell structure.

Multiple independent nested stent structures and methods for their preparation and deployment

Growing community of inventors

Portola Valley, CA, United States of America

Jeffry J Grainger