Alexion Pharmaceuticals, Inc.

Jeffrey William Hunter

Paul P Tamburini

Douglas L Sheridan

Andre Marozsan

Hunter F Malanson

Anjli Kukreja

Julian Chandler

Rahul Godawat

Abraham Friedman

Keith Bouchard

Patricia Bento

Kyle A Zingaro

Anjil Giri

Justin Weaver

Saranya Sivanandam

Jeffrey Zugates

Provided herein are antibodies that bind to activin receptor-like kinase 2 (ALK2) and are useful for treating bone disorders, such as those involving reduced bone mineral density and bone mineralization defects, and promoting bone growth. Also provided are polynucleotides encoding the antibodies, vectors comprising the polynucleotides, and cells that produce the antibodies.

Anti-ALK2 antibodies and uses thereof

The present application relates to a method of producing an anti-C5 antibody (ravulizumab), wherein the method comprises: —culturing mammalian cells comprising a nucleic acid encoding the anti-C5 antibody in a cell culture production medium—Performing two or more steps selected from the group consisting of: a recovery step; purification by Protein A affinity chromatography, a low pH viral inactivation step; Purification by cation exchange chromatography; Purification by anion exchange chromatography; a virus reduction filtration step; and a concentration and diafiltration step.

Methods of producing anti-C5 antibodies

This invention relates to humaneered anti-factor B antibodies and antigen-binding fragments thereof with modified glycosylation patterns. The humaneered anti-factor B antibodies and antigen-binding fragments thereof are derived from murine monoclonal antibody 1379, which binds factor B in the third short consensus repeat ('SCR') domain and selectively inhibits activation of the alternative complement pathway by preventing formation of the C3bBb complex. The invention also relates to methods of treating diseases or disorders in which activation of the alternative complement pathway plays a role, and methods of selectively inhibiting activation of the alternative complement pathway in an individual in need thereof.

Humaneered anti-factor B antibody

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Wallingford, CT, United States of America

Jeffrey William Hunter