Eth Zurich

Jeffrey William Bode

Benedikt Matthias Wanner

Vijaya Pattabiraman

Kuang-Yen Chen

Paula Louise Nichols

Hidetoshi Noda

Gabor Eros

Dmitry Mazunin

Yi-Lin Huang

Provided is an process for the automated synthesis of at least one chemical compound including providing at least one substrate in at least one solvent in the at least one reaction container; automatically passing the at least one substrate through at least one first compartment of the at least one cartridge once or several times and collecting a formed substrate-reagent intermediate product in the at least one reaction container prior to passing the substrate-reagent intermediate product into a subsequent compartment; automatically passing the substrate-reagent intermediate product through at least one second compartment once or several times and collecting a formed reaction product prior to passing the reaction product into a subsequent compartment; automatically passing the reaction product through at least one third compartment for purifying the product once or several times and collecting a purified product in the at least one reaction container.

Apparatus and process for the automated chemical synthesis of compounds

Provided is an apparatus for the automated synthesis of at least one chemical compound including: at least one cartridge including at least one first compartment for providing at least one first reagent for the chemical synthesis of the at least one compound; at least one second compartment for providing at least one second reagent for the chemical synthesis of the at least one compound, and at least one third compartment for purifying the at least one synthesized compound; at least one reaction container for providing the compounds to be fed into at least one of the compartments of the cartridge and/or collecting the reaction product from at least one of the compartments of the cartridge; at least one solvent container at least two flow path selecting valves and at least one pump.

Polyethylene glycol substituted acyl borates, methods for their preparation, and the use of the polyethylene glycol substituted acyl borates for the preparation of polyethylene glycol substituted macromolecules. The polyethylene glycol substituted acyl borate has the general formula (I) wherein PEG denotes a polyethylene glycol-based substituent; a is an integer from 1 to 12; X1, X2, and X3 are independently of one another selected from the group made of F, OR, N+R3, N+R2OR, N+R2SR, and N+R2NR2, and are optionally forming a cyclic or a bicyclic structure; and R is an organic substituent or H.

Polyethylene glycol substituted acyl borates

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Zurich, Switzerland

Jeffrey William Bode