The General Hospital Corporation

Massachusetts Institute of Technology

Jeffrey W Clark

Robert Samuel Langer

Elazer Reuven Edelman

David Borsook

Robert S Langer, Jr

David T Ting

Matteo Ligorio

Laura Indolfi

Cristina Rosa Annamaria Ferrone

Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 &#x3bc;m to about 1000 &#x3bc;m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

Local drug delivery devices and methods for treating cancer

Methods of providing pain relief which includes the steps of identifying an animal in need of pain relief and administering an amount of spicamycin or a derivative thereof sufficient to provide pain relief.

Methods of decreasing or preventing pain using spicamycin or derivatives

Growing community of inventors

Chestnut Hill, MA, United States of America

Jeffrey W Clark