Qiagen Genomics, Inc.

Darwin Discovery Limited

Microprobe, Inc.

Operon Biotechnologies, Inc.

Becton Dickinson and Company Limited

Ucb Pharma, S.a.

Keck Graduate Institute

Rapigene, Inc.

Novo Nordisk A/s

Zymogenetics, Inc.

Ucb S.a.

Celltech R&d Limited

Ucb Manufacturing, Inc.

Jeffrey Van Ness

John Thomas Mulligan

John C Tabone

David J Galas

Brian Robert Kovacevich

Mary E Brunkow

Bryan W Paeper

J Jeffry Howbert

David Guenther Winkler

Nicolaas M Vermeulen

Kristen Moynihan

Charles R Petrie

B Melina Cimler

David J Winkler

Lori K Van Ness

Michael W Reed

Rich B Meyer, Jr

Robert R West

Annemarie Reinhardt Varming

Nicolaas M Vermuelen

Lori K Garrison

A novel class or family of TGF-&#x3b2; binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

Compositions and methods for increasing bone mineralization

Described herein are pharmaceutical compositions comprising an anti-sclerostin antibody and an inhibitor of bone resorption.

Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&#x3b2; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.

Antibodies associated with alterations in bone density

Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.

Methods and compositions for determining the sequence of nucleic acid molecules

Nucleic acids relating to human TGF-&#x3b2; binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

Antibodies to a novel family of TGF-&#x3b2; binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.

Methods for modulating bone mineralization

The present invention provides methods and kits for amplifying target nucleic acids (including whole genomes) using nicking agents. In certain aspects, the amplification does not require the use of any external oligonucleotide primers that are capable of annealing to a portion of the target nucleic acid. This invention is useful in many areas such as genetic disease diagnoses, forensic analyses and palcoarcheological studies.

Nucleic acid amplification using nicking agents

Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required.

Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques

The present invention provides methods and compositions for nucleic acid methylation analysis using nicking agents.

Methylation analysis using nicking agents

Methods are provided for detecting the binding of a first member to a second member of a ligand pair, comprising the steps of (a) combining a set of first tagged members with a biological sample which may contain one or more second members, under conditions, and for a time sufficient to permit binding of a first member to a second member, wherein said tag is correlative with a particular first member and detectable by non-fluorescent spectrometry, or potentiometry, (b) separating bound first and second members from unbound members, (c) cleaving the tag from the tagged first member, and (d) detecting the tag by non-fluorescent spectrometry, or potentiometry, and therefrom detecting the binding of the first member to the second member.

Methods and compositions for enhancing sensitivity in the analysis of biological-based assays

Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-&bgr; binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.

Growing community of inventors

Claremont, CA, United States of America

Jeffrey Van Ness