Biogen Idec Ma Inc.

Biogen Ma Inc.

Apoxis S.a.

Topotarget Switzerland Sa

Biogen Idcc Ma Inc.

Apotech R&d S.a.

Jeffrey Thompson

Christine Ambrose

Pascal Schneider

Jeffrey L Browning

Yen-Ming Hsu

Jurg Tschopp

Dingyi Wen

Fabienne MacKay

Yaping Sun

Paul David Rennert

Teresa Cachero

Christine M Ambrose

Fabienne Mackay

A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.

Methods of modulating immune responses using BCMA polypeptide

Methods of treating autoimmune diseases using a B-cell maturation antigen (BCMA)

Methods of screening for a compound that inhibits the interaction between BAFF and BCMA

The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.

Method of treating B cell cancers by administering truncated BAFF receptors

Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.

Method for inhibiting BAFF-R activity

The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.

Method of treating immunological disorders by administering truncated BAFF receptors

Method of identifying compounds that bind BAFF-R

Truncated BAFF receptors

Methods of monitoring treatment of BAFF-R related disease

Truncated baff receptors

BAFF receptor antibodies and methods

BAFF receptor polypeptides

A novel receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.

Methods of treating a tumor that expresses APRIL by administering BCMA

Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided.

Nucleic acids encoding BAFF receptor, chimeric proteins and methods and compositions related thereto

Methods of treatment by administering an anti-BCMA antibody

Growing community of inventors

Stoneham, MA, United States of America

Jeffrey Thompson