Cytokinetics, Inc.

Five Prime Therapeutics, Inc.

Jeffrey T Finer

Roman Sakowicz

John Clifford Chabala

Bainian Feng

Whitney Walter Smith

Gustave Bergnes

Fady Malik

Kenneth Wood

Bradley Paul Morgan

David John Morgans, Jr

Pu-Ping Lu

James Hartman

Christophe Beraud

Christopher Bentley Shumate

Xiangping Qian

Alex R Muci

Chihyuan (Grace) Chuang

Alan James Russell

John Mak

Ramesh Baliga

Daniel W Pierce

Donglin Guo

Lewis T Williams

Kevin Hestir

Shannon Marshall

Kalyani Penta

Srinivas Kothakota

Yan Wang

Gustav E Bergnes

Gustav S Bergnes

David J Morgans

Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. 

Methods and compositions utilizing quinazolinones

Quinazolinones of formulae 1, 1, 1and 1are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. 

The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.

Compositions for treating arthritis comprising HG1023575 polypeptide

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.

Certain chemical entities, compositions and methods

Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

Certain chemical entities, compositions, and methods

Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. 

Methods and compostions utilizing quinazolinones

Provided is at least one chemical entity chosen from compounds of Formula I and Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.

Certain 1H-imidazo[4,5-B]pyrazin-2(3H)-ones and 1H-imidazo[4,5-B]pyrazin-2-ols, compositions thereof, and methods for their use

Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.

The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or serve as modulators of the biological activity of a target protein.

High sensitivity assay for detection of nucleoside diphosphate production

Quinazolinone KSP inhibitors

Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating of one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.

Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use

Growing community of inventors

Foster City, CA, United States of America

Jeffrey T Finer