Becton Dickinson and Company Limited

Jeffrey Sugarman

Edward M Goldberg

Ming Tan

Scott Bornheimer

Justin Morton

Amirthaganesh Subramanian

Chiming Frank Huang

The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing of the sample and reagent without filtering the sample.

Microfluidic devices, and methods of making and using the same

Aspects of the present disclosure include methods for separating components having different densities from a biological sample droplet. Methods according to certain embodiments include contacting a surface of a support with a biological sample droplet that includes components of different densities; subjecting the biological sample droplet to a gravitational force to produce two or more regions in the biological sample droplet on the support surface, where each region in the biological sample droplet includes a component from the biological sample droplet having a different density; separating the biological sample droplet into two or more product droplets, wherein each product droplet includes a different region of the biological sample droplet; and collecting the one or more product droplets. Systems for practicing the subject methods are also described. Computer systems and kits are also provided.

Methods and systems for separating components of a biological sample with gravity sedimentation

The present disclosure provides methods and systems for analyzing a liquid sample. A micro-fluidic device to perform an assay of a liquid sample is described that includes a sample application site and a vent outlet in fluid communication with the capillary channel. A cap is provided that is configured to seal both the vent outlet and the sample application site in a shared volume and separate from an outside environment.

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Los Altos, CA, United States of America

Jeffrey Sugarman