North Carolina State University

Sicel Technologies, Inc.

Snc Holdings Corp.

Other

Sicel Techonologies, Inc.

Jeffrey S Mueller

H Troy Nagle

Charles W Scarantino

Lester C Hall

Bahram Ghaffarzadeh Kermani

Arthur W Kelley

Ronald S Gyurcsik

Chang-Soo Kim

Leslie C Hall

Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide radiation data associated with the tumor treatment site; and (b) a first portable receiver in communication with the plurality of sensors. The receiver is configured to obtain radiation data from the sensors at a plurality of different times. The receiver is in communication with a local and/or remote computer that tracks variation in the radiation data to provide dynamic tumor site information.

Methods and systems for monitoring patients undergoing treatment for cancer

Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.

Implantable devices for dynamic monitoring of physiological and biological properties of tumors

Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.

Methods, systems, and associated implantable devices for detecting radiation in patients undergoing treatment for cancer

Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into tile first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.

Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors

Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.

Methods, systems, and associated implantable devices for radiation dose verification for therapies used to treat tumors

Magnetic Vector Steering (MVS) and Half-Cycle Amplitude Modulation (HCAM) are novel techniques which enhance the powering and control of multiple arbitrarily oriented implant devices. Together, these techniques enable arbitrarily oriented implants to receive power and command, programming, and control information in an efficient manner that preserves battery life and transmission time while reducing overall implant device bulk. By steering the aggregate magnetic field from a near-orthogonal set of AC-energized coils, selected implants can be powered or communicated with at desired times. Communication with individual implants can also be enhanced through half-cycle amplitude modulation &mdash;a technique that allows bit rates up to twice the energizing frequency. Unlike prior art systems, power and data transfer can be realized over the same frequency channel.

System and method for powering, controlling, and communicating with multiple inductively-powered devices

Magnetic Vector Steering (MVS) and Half-Cycle Amplitude Modulation (HCAM) are novel techniques which enhance the powering and control of multiple arbitrarily oriented implant devices. Together, these techniques enable arbitrarily oriented implants to receive power and command, programming, and control information in an efficient manner that preserves battery life and transmission time while reducing overall implant device bulk. By steering the aggregate magnetic field from a near-orthogonal set of AC-energized coils, selected implants can be powered or communicated with at desired times. Communication with individual implants can also be enhanced through half-cycle amplitude modulation&mdash;a technique that allows bit rates up to twice the energizing frequency. Unlike prior art systems, power and data transfer can be realized over the same frequency channel.

Magnetic Vector Steering (MVS) and Half-Cycle Amplitude Modulation (HCAM) are novel techniques which enhance the powering and control of multiple arbitrarily oriented implant devices. Together, these techniques enable arbitrarily oriented implants to receive power and command, programming, and control information in an efficient manner that preserves battery life and transmission time while reducing overall implant device bulk. By steering the aggregate magnetic field from a near-orthogonal set of AC-energized coils, selected implants can be powered or communicated with at desired times. Communication with individual implants can also be enhanced through half-cycle amplitude modulation--a technique that allows bit rates up to twice the energizing frequency. Unlike prior art systems, power and data transfer can be realized over the same frequency channel.

Growing community of inventors

Raleigh, NC, United States of America

Jeffrey S Mueller