Pacira Pharmaceuticals, Inc.

Other

Jeffrey S Hall

John J Grigsby, Jr

Kathleen D A Los

Soroush M Ardekani

David J Turnbull

Louie Daniel Garcia

Stephanie M Kurz

Paige N Davis

Eran Levy

Richard A Katz

Douglas Sawyer

Albert H Nuttall

Tracey A Dodenhoff

Embodiments of the present disclosure relates to a new and improved large scale commercial manufacturing process of making bupivacaine multivesicular liposomes (MVLs). Batches of bupivacaine MVLs prepared by the new process have high yields, improved stabilities, and desired particle size distributions.

Manufacturing of bupivacaine multivesicular liposomes

Embodiments of the present application relate to compositions bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process with large particle diameter span.

Embodiments of the present disclosure relates to commercial manufacturing process of making bupivacaine multivesicular liposomes with improved yield and desired particle size distribution.

Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.

Embodiments of the present application relate to compositions of multivesicular liposomes (MVLs) and manufacturing processes for making bupivacaine MVLs.

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San Diego, CA, United States of America

Jeffrey S Hall