Smithkline Beecham Corporation

Jeffrey S Culp

Catherine E Ellis

Christine Marie Debouck

Sherin Salaheldin Abdel-Meguid

Cheryl Ann Janson

Dean E McNulty

Xiayang Qiu

Ward Whitlock Smith, Jr

Susan S Hoog

Derk J Bergsma

Ganesh Madhusudan Sathe

Wendy S Halsey

Da-Yuan Wang

Human Urotensin II polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human Urotensin II polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Human urotensin II

HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods of screening for agonists and antagonists of the interaction between the HDPXU17 receptor and its ligands, dexoyadenosine triphosphate ('dATP'), deoxyadenosine monophosphate ('dAMP'), and uridine triphosphate ('UTP').

Methods of screening for agonists and antagonists of the HDPXU17 receptor

Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.

Proteases compositions capable of binding to said site, and methods of

Proteases, compositions capable of binding to said site, and methods of

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Collegeville, PA, United States of America

Jeffrey S Culp