Arbor Biotechnologies, Inc.

Jeffrey Raymond Haswell

Quinton Norman Wessells

Noah Michael Jakimo

Tia Marie Ditommaso

Sejuti Sengupta

Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.

Gene editing systems comprising an RNA guide targeting lactate dehydrogenase a (LDHA) and uses thereof

Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.

Growing community of inventors

Needham, MA, United States of America

Jeffrey Raymond Haswell