Duke University

Genaissance Pharmaceuticals, Inc.

Jeffrey R Marks

James Dirk Inglehart

Marco Guida

Jeff Hall

Jerry G Henslee

James P Vaughn

Oliver M Colvin

James J Vredenburgh

William P Petros

Andrew Mark Davidoff

Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which have been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.

Methods for evaluating the ability to metabolize pharmaceuticals

Oligonucleotides consisting of the nucleotide sequence US-3 �GGT GCT CAC TGC GGC (SEQ ID NO:2)! or UT-1 �TGC GGC TCC GGC CCC (SEQ ID NO:5)!. The oligonucleotides are useful as antisense oligonucleotides for inhibiting the expression of the ERBB2 tyrosine kinase receptor in a cell, in vitro or in vivo.

Antisense oligonucleotides against ERBB-2

The present invention relates to the finding that the class of mutant p53 proteins which bind to HSP70 defines a group of mutant p53 proteins which elicit serum autoantibodies. Thus, disclosed is a method of classifying tumor cells for the ability to produce serum p53 autoantibodies in a patient carrying such tumor cells, a method of detecting tumor cells containing a mutant p53 protein capable of forming a complex with a 70 kilodalton heat shock protein (hsp70) in the cells in a patient, a method of distinguishing tumor cells capable of causing more aggressive disease in a patient carrying the tumor cells, and a method of monitoring a patient for the recurrence of disease in a patient previously diagnosed as carrying tumor cells.

Method of detecting tumors containing complexes of p53 and HSP70

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Hillsborough, NC, United States of America

Jeffrey R Marks