Endoshape, Inc.

University of Colorado

Forcast Orthopedics, Inc.

Meridian Medical Technologies, Inc.

Allotrope Medical, LLC

Jeffrey Paul Castleberry

Julie Marie Trommeter

William N Aldrich

Michael B Lyons

Charles Barkenbus

Robin Shandas

Stan Needle

Frank P Becking

Stephen Dean Goodrich

Jessi Watson

Jared Ruben Hillel Foran

James Fogelberg

Dean Carson

Paul Burek

Jon Page

Malik Y Kahook

Keir Hart

Stephen A Johnson

John Glyndwr Wilmot

Robert L Hill

Naresh Mandava

David G Matsuura

Cliff Ketcham

Devatha P Nair

Bryan Rech

Jacob A Moebius

Philip J Simpson

Robert R Boyd

Timothy Francis Scott

Albert Yung-Hsiang Huang

Avery Nelson

Jeffrey L Goldberg

Jason Morton

Dave Edsall

Nishant Verma

Leo Whiteside

An implantable externally driven fluid delivery system for localized delivery of medical agents and drugs, such as antibiotics, may be provided herein. The fluid delivery system includes a housing that incorporates a filling septum connected to a flexible internal reservoir. The reservoir is connected to a miniature diaphragm pump with coupled magnetic components. The entire fluid delivery system is implantable into a body cavity or surgically formed location that provides for local medical agent delivery. The reservoir is filled via percutaneous injection through the skin into the septum. Fluid delivery is achieved through proximity of the external controller that generates an oscillating or reversing magnetic field suitable to actuate the pump's diaphragm resulting in controlled fluid flow. Once local drug delivery treatment is complete, the controller can be discarded.

Implantable externally driven fluid delivery system

A spacer for a knee replacement prosthesis may be provided. The spacer may include a lower surface, the lower surface having a locking component adapted to interlock with a tibial tray; an upper surface, the upper surface having an optional central femoral guide and a pair of condyle support platforms, each of the condyle support platforms being disposed on an opposite side of the central femoral guide, each of the condyle support platforms being smooth, the surface of each of the condyle support platforms further having a shallow concavity; and a body incorporating the upper and lower surfaces, the body having a hollow outer portion surrounding an internal reservoir, the body being impermeable to fluid; the body further having one or more ports, each with a channel, each channel extending through the hollow outer portion of the body directing the flow of fluid in and out of the port(s).

Method, system, and apparatus for antibiotic dispensing knee prosthesis

An electrical stimulation system includes a stimulator having at least one electrode and a power supply. The electrode is connectable to the power supply, and the power supply delivers electrical stimulation energy in the form of a capacitive discharge voltage through the stimulator and electrode to tissue proximate a target anatomy to induce an observable response in the target anatomy during a medical procedure.

Delivery system for intracorporeal smooth muscle stimulation

An occlusion device for a vascular or biological lumen includes a plurality of coiling members held together at both the proximal and distal ends by retaining features. A restraining loop can hold coiling members together at a point along a length of the coiling members. The coiling members are delivered simultaneously to form a coil pack to occlude a target location in the lumen. One or more of the coiling members has at least a portion with a larger curl diameter than other coiling members to secure the occlusion device against lumen walls at the target location. The coil members may have different or varying material moduli. The device may be used, for example, for occluding a vessel to block blood flow to an artery supplying blood liver (hepatic artery), kidney (renal artery), spleen (splenic artery) or intestines (mesenteric artery).

Occlusion device for a vascular or biological lumen

Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional monomer and a second repeating unit derived from a crosslinker monomer or oligomer having more than two polymerizable groups. Devices formed from radiopaque polymer compositions are also provided.

Polymer compositions with enhanced radiopacity

A delivery apparatus for a lumen occlusion device includes a pusher configured for releasably coupling with and pushing and pulling a proximal end of the occlusion device in a distal or proximal direction and a distal control wire capable of releasably coupling with the distal end and the proximal end of the occlusion device. The control wire may be configured for moving the distal end of the occlusion device in both proximal and distal directions allowing precise simultaneous control of both proximal and distal ends of the occlusion device. Control of both ends provides for placing the occlusion device in tension during delivery through a delivery catheter, thereby reducing delivery forces, achieving greater compaction of the occlusion device in the lumen, and precisely locating both distal and proximal ends of the occlusion device within the lumen.

Systems, devices, and methods for delivering a lumen occlusion device using distal and/or proximal control

An occlusion system () provides a trimmable continuous embolic coil () that is 'cut to length' at the end of its deployment into the target occlusion site. A delivery device () provides the 'cut to length' feature for the continuous embolic coil.

Continuous embolic coil and methods and devices for delivery of the same

Shape memory materials (SMM) are formed as coil-shaped vascular occlusion devices upon deployment. Shape memory polymer (SMP) materials are tailored through formulation for specific mechanical behavior of the coils. Concurrent coil diameter changes enhance the relative change in stiffness along the length of the coil. Interconnecting structures () are formed on ends of elongated members () in the pre-deployment shape for multiple coil insertion capability within an introducer. Channels () are formed in pre-deployment shape, elongate members () that allow access for injection of imaging contrast agent or concurrent placement of instruments. A single SMM occlusive device () transforms into multiple, smaller diameter coils () in the deployed state to generate a complex occlusive structure. A SMM occlusive device () has a collapsed fabric () component attached to and extending along a sidewall during storage and insertion, and then deploys as a coil () to form a single- or multiple-layer occlusive fabric surface within a center of the coil ().

Vascular occlusion devices

A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.

Shape memory polymer prosthetic medical device

Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include shape memory polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional iodinated monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.

Radiopaque shape memory polymers for medical devices

An implantable ophthalmological device () in the form of a punctal plug or canalicular implant is configured for use at or near the nasolacrimal drainage system. In a deployed state, the device () may include an elongated body (), an anchor () operably connected to the elongated body (), a radially expanding occlusive feature disposed on an outer circumference of the elongated body (), and a flange (). The elongated body () may define a lumen () configured to receive a pharmacological treatment (). The device () is made of a shape memory material such as a shape memory polymer.

Reliably retained shape memory ophthalmological implants

The present invention relates to an automatic injector having a drive assembly with an actuator extending from the rearward end portion of the housing and a removal resistant cover for preventing unintended operation of the actuator. The present invention also relates to a sealing arrangement wherein the needle is sealed within a sterilized needle chamber by at least three sealing members which cooperate to form the chamber. Also, the present invention relates to an injector in which the cartridge is mounted to a tubular cartridge mounting portion of the needle carrier with an annular sealing member disposed therebetween. The cartridge mounting portion has at least one generally axially extending groove which allows air to escape from the cartridge mounting portion as the cartridge is being moved forwardly to a medicament supplying position.

Automatic injector

Growing community of inventors

Longmont, CO, United States of America

Jeffrey Paul Castleberry