Insite Vision Corporation

Other

Jeffrey P Davis

Santosh K Chandrasekaran

Roy D Archibald

Joseph R Robinson

Christa D Nicholas

Yansheng Su

Lightly crosslinked polymers, preferably ones prepared by suspension or emulsion polymerizing at least about 90% by weight of a carboxyl-containing monoethylenically unsaturated monomer such as acrylic acid with from about 0.1% to about 5% by weight of a polyfunctional, and preferably difunctional, crosslinking agent such as divinyl glycol (3,4-dihydroxy-1,5-hexadiene), having a particle size of not more than about 50 .mu.m in equivalent spherical diameter, when formulated with an ophthalmic medicament, e.g., fluorometholone, into suspensions in aqueous medium in which the amount of polymer ranges from about 0.1% to about 6.5% by weight, based on the total weight of the aqueous suspension, the pH is from about 3.0 to about 6.5, and the osmotic pressure (osmolality or tonicity) is from about 10 mOsM to about 400 mOsM, provide new topical ophthalmic medicament delivery systems having suitably low viscosities which permit them to be easily administered to the eye in drop form, and hence be comfortably administrable in consistent, accurate dosages. These suspension will rapidly gel in the eye after coming into contact with the eye's tear fluid to a substantially greater viscosity than that of the originally-introduced suspension and thus remain in place for prolonged periods of time to provide sustained release of the ophthalmic medicament.

Ophthalmic suspensions

A disposable unit- or multi-dose liquid dispensing container device, particularly adapted for delivery of ophthalmic liquid medicament in the form of discrete droplets to the eye. The structural configuration of the device including an angularly offset leading end permits the user to employ a free hand for manipulation of the eyelid to enhance reception of the discharge opening of the dispenser into the conjunctival cul-de-sac while at the same time, enabling the user to look directly into a wall-mounted mirror for accurate placement of the medicament. A small capacity reservoir and ease of control of accurate orifice size enables the application of uniform liquid-ejection pressure by the user to deliver droplets of reproducible dosage size with the multi-dose embodiment.

Liquid droplet dispensing apparatus

A device for detecting keratoconjunctivitis sicca (KCS) utilizing a probe including a body having an end portion. A plurality of electrical contacts are mounted in spaced configuration at the end portion of the probe body for simultaneous contact with the tear fluid of the ocular conjunctiva, or components thereof. An electrical potential is applied to at least one of the plurality of the electrical contacts and electrical activity, such as conductance, between the one electrical contact to another electrical contact is measured relative and the interposed tear fluid.

Growing community of inventors

Madison, WI, United States of America

Jeffrey P Davis