Boehringer Ingelheim (canada) Ltd.

Boehringer Ingelheim International Gmbh

Jeffrey O'Meara

Christiane Yoakim

William W Ogilvie

Bruno Simoneau

Robert D&eacute;ziel

Nathalie Goudreau

Bounkham Thavonekham

Peter White

Serge R Landry

Anne-Marie Faucher

Sebastien Morin

Julie Naud

Alexandre Gagnon

Patrick Deroy

Eric Malenfant

Dale R Cameron

Stephen Kawai

Catherine Chabot

Robert Déziel

Bruno Hach&eacute;

Bruno Hache

Compounds of formula (I): wherein Ar, X, R, R, Rand Rare as defined herein. The compounds are useful as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV.

Non-nucleoside reverse transcriptase inhibitors

A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R, Y; R; and Rare as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Inhibitors of papilloma virus

Disclosed herein are compounds of formula Ar&#x2014;X&#x2014;W&#x2014;Arwherein Arand Arrepresent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)-N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.

Compounds of formula (I): wherein R, R, R, R, Rand Rare as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. In particular, the compounds are active against wild type and single or double mutant strains of HIV.

Benzoic acid derivatives as non nucleoside reverse-transcriptase inhibitors

A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R, Y; R; and Rare as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.

Non nucleoside reverse transcriptase inhibitors

Compounds represented by formula 1: wherein Ris H, halogen, (C)alkyl, O(C)alkyl, and haloalkyl; Ris H or methyl; Ris H or (C)alkyl; Ris H or (C)alkyl; Ris (C)alkyl, (C)alkyl(C)cyclo-alkyl or (C)cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1'-biphenyl, 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C)alkyl, which in turn can be optionally substituted with a carboxy or (C)alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.

Azetidinone derivatives for the treatment of HCMV infections

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Boisbriand, Canada

Jeffrey O'Meara