The Brigham and Women's Hospital, Inc.

Massachusetts Institute of Technology

Children's Medical Center Corporation

Biocant-center of Innovation and Biotechnology

Harvard College

Other

The State University of New York

The Charles Stark Draper Laboratory, Inc.

The Broad Institute, Inc.

Jeffrey Michael Karp

Robert Samuel Langer

Yuhan Lee

Omid C Farokhzad

Lino Da Silva Ferreira

Bryan Laulicht

Christopher J Bettinger

Andreas Zumbuehl

Praveen Kumar Vemula

Xiaolei Yin

Debanjan Sarkar

Nitin Joshi

Pedro J Del Nido

Jason Alan Burdick

Joost P Bruggeman

Christiaan Nijst

Ali Tavakkoli

Tarawatie E Deelman

Sonia J Kim

Eoin D O'Cearbhaill

Maria Jose Maio Nunes-Pereira

Ben Ouyang

Daniel Griffith Anderson

Rohit Nandkumar Karnik

Seungpyo Hong

Suman Bose

Sufeng Zhang

Robert S Langer

Abdullah M Syed

Alexander H Slocum, Jr

Conor James Walsh

Panagiotis Polygerinos

Nikolay V Vasilyev

Veaceslav Arabagi

Peter E Hammer

Ellen T Roche

Steven Charles Wasserman

Bohdan Pomahac

Erik Bassett

Jeffrey T Borenstein

Alexander H Slocum

David J Carter

Pamela A Basto

Alexander K Shalek

George John

Amit Choudhary

Robert S Langer, Jr

Janet Freilich

Nathaniel R Campbell

Ying Mei

Marc David Succi

Assunta Fabozzo

Haruo Yamauchi

Eric N Feins

Douglas P Perrin

Seung Yun Yang

Robert Langer

Lucia R Schuster

Ingeborg Friehs

Nikken Wiradharma

Kai Vincent Slaughter

Maria Jose M N Pereira

Maria Jose Pereira

Edwin P Chan

Eoin O'Cearbhaill

Miseon Lee

Jose Ordovas-Montanes

Archana Swami

Woo-Kyung Cho

Mahdavi Alborz

Lino Ferreira

Greg Cruikshank

Ronald A Karp

Kisuk Yang

Benjamin E Mead

Girish Chitnis

Douglas Rioux

Julien Lamazouade

Nicholas Edward Sherman

Mohan K S Verma

Andrew John Pickering

Peter Jones

Connor Francis Gallin

Xueyin He

Sachin Bhagchandani

Nora Lang

Woo Kyung Cho

Lino Da Silva-Ferreira

Maria Jose MN Pereira

Lucia Schuster

Fabozzo Assunta

3D cell cultures and devices for 3D cell culture, and methods of use thereof are provided. In some embodiments, the 3D cell culture comprise pancreatic β cells and can be generated in multi-well plates, allowing for high throughput assays on the cell culture.

Three-dimensional cell culture, devices, and use thereof

Disclosed here is a generally applicable framework that utilizes massively-parallel single-cell RNA-seq to compare cell types/states found in vivo to those of in vitro models. Furthermore, Applicants leverage identified discrepancies to improve model fidelity. Applicants uncover fundamental gene expression differences in lineage-defining genes between in vivo systems and in vitro systems. Using this information, molecular interventions are identified for rationally improving the physiological fidelity of the in vitro system. Applicants demonstrated functional (antimicrobial activity, niche support) improvements in Paneth cell physiology using the methods.

Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity

Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

Nanostructured gels capable of controlled release of encapsulated agents

This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.

Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients

Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-), wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.

Urethane-crosslinked biodegradable elastomers

An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.

Insertable catheter device for patch application

This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.

Compounds to modulate intestinal absorption of nutrients

This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.

Drug delivery composition comprising a self-assembled gelator

The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

Method comprising contacting tissue with a cross-linkable polyester prepolymer

An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.

Autonomously growing implantable device

A system for delivering an injection of a fluid into a void within a subject is disclosed. A barrel extends from a first end to a second end and forms a lumen extending from the first end to the second end. A plug and a floating seal are arranged within the lumen. A hollow needle includes a distal end with an opening for fluid to flow from the lumen. The plug, the barrel and the floating seal include material and dimensions selected based on a threshold flowrate for a fluid arranged within the lumen to: overcome a force opposed to a force being applied to the fluid in the lumen to move the floating seal and the hollow needle into a tissue of the subject, and succumb to the opposing force to displace the fluid through the opening into the void.

System and method for resistance-dependent, self-regulated medical penetration

Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss

This disclosure relates to swellable needles that include a proximal end portion and a swellable distal end portion. Upon exposure to a liquid, the needles are configured to undergo a shape change from a first configuration in which the width of the needle is tapered from the proximal end portion to the distal end portion to a second configuration in which the distal end portion is more swollen than the proximal end portion. The swellable needles can be double layer swellable needles or single material swellable needles.

Swellable adhesive needles

Growing community of inventors

Chestnut Hill, MA, United States of America

Jeffrey Michael Karp