General Electric Company

Ge Precision Healthcare LLC

Lockheed Martin Corporation

Albany Medical College

University Health Network

Ge Security, Inc.

Ge Intellectual Property Licensing, LLC

Jeffrey Michael Ashe

Christopher Michael Puleo

Victoria Eugenia Cotero

David Andrew Shoudy

Ileana Hancu

Ying Fan

John Frederick Graf

Seth D Silverstein

Kirk Dennis Wallace

James Enrico Sabatini

Radislav Alexandrovich Potyrailo

Emad Andarawis Andarawis

Kenneth Brakeley Welles

David Michael Davenport

Gregory Boverman

Bruce Courtney Campbell Amm

Tzu-Jen Kao

Richard Louis Zinser

Ralph Thomas Hoctor

Christopher Fred Keimel

Erik Lier

Naresh Kesavan Rao

Kaustubh Ravindra Nagarkar

Paul Edward Cuddihy

Warren Lee

Anthony Wykeham Jacomb-Hood

Craig Patrick Galligan

Nancy Cecelia Stoffel

Alexander Seth Ross

Krishnakumar Sundaresan

Eric William Fiveland

Michael Ernest Marino

Yang Zhao

Robert Leland Nevin

Suresh Emmanuel Joel

Radhika Madhavan

Asha Singanamalli

Gregory Michael Kautz

Daniel Sanford Purdy

Sm Shajed Hasan

Amit Satish Gore

Nicholas George Richard

John Erik Hershey

Christopher James Kapusta

Peter Henry Tu

Weston Blaine Griffin

Frederick Wilson Wheeler

Robert C Davis

Nick Andrew Van Stralen

Yizhen Lin

Pierino Gianni Bonanni

William Hullinger Huber

Graeme Colin McKinnon

Andres M Lozano

Juha Virtanen

Harold Woodruff Tomlinson, Jr

Matthew Jeremiah Misner

Jens Rittscher

William Guy Morris

Naofal Mohammed Al-Dhahir

Richard Louis Frey

Kai Erik Thomenius

Aaron Judy Couture

Jason Harris Karp

Selaka Bandara Bulumulla

Siavash Yazdanfar

Thomas Baby Sebastian

Ralf Lenigk

Timo J Toivanen

Guanghan Xu

Richard Vanfleet

Otto Valtteri Pekander

Cheryl Margaret Surman

Benjamin Edward Beckmann

Ting Yu

Sahika Genc

Tarik Yardibi

Vladimir Volman

Andrew A Burns

Sathish Ramani

Richard Charles Gaus, Jr

Corey Nicholas Bufi

GianFranco Doretto

Nils Oliver Krahnstoever

Ashraf Said Atalla

Aharon Yakimov

Azar Alizadeh

Xiaohui Chen

Daniel Joseph Cleary

John Joseph Freer

David William Vernooy

Vincent Paul Staudinger

Victor Robert Abate

Paul Jeffrey Gillespie

John Charles Hill, Jr

Khalil John Maalouf

Joseph John Fisher

Alexandre Boutet

Milos Todorovic

Rolf Feodor Schulte

Combined neuromodulation techniques are disclosed to treat metabolic disorders. The combined neuromodulation techniques may include dual-site neuromodulation or single-site neuromodulation. In embodiments, the neuromodulation may be administered as a combined therapy with a pharmaceutical treatment.

Combined neuromodulation techniques

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue to cause altered activity at a synapse between a neuron and a non-neuronal cell.

Techniques for neuromodulation

Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.

Delivery of therapeutic neuromodulation

The present approaches are generally directed to facilitating healing of wounds, including chronic wounds typically associated with slow heal times or which are persistent. In one embodiment, a method of promoting wound healing comprises positioning an ultrasound transducer at a stimulation site on a subject having a wound. Pulsed focused ultrasound (pFUS) is non-invasively applies using the transducer to cause modulation of a target anatomic site containing resident or circulating immune cells. Modulation of the target anatomic site of the subject causes migration of one or more of monocytes, macrophages, or neutrophils to a wound bed of the wound.

Accelerating cutaneous healing utilizing non-invasive focused ultrasound

The subject matter of the present disclosure generally relates to techniques for applying focused ultrasound energy to a region of interest in a subject to induce neuromodulation of the celiac plexus to treat inflammatory bowel disease. The region of interest ay include at least a portion of a peripheral ganglion of the celiac plexus.

Neuromodulation to treat physiological conditions

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Neuromodulation techniques for perturbation of physiological systems

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Noninvasive tissue displacement control and monitoring for neuromodulation

The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation.

The present discussion relates to the delivery of ultrasonic therapy energy to a target region in conjunction with a clear path determination that may assess one or more of: (1) presence of non-soft tissue regions within the therapy beam path (e.g., bone or bone-like structures, gas-filled cavities, and so forth), (2) partial 'lift-off' of the probe head; or (3) sufficiency of acoustic coupling. Upon determination or confirmation of at least a partial clear path with respect to some or all of these factors, the therapy beam may be delivered to the target region.

Ultrasonic beam path determination and targeting

Techniques for accurate positioning of an energy application device for neuromodulation treatment protocols are provided. A neuromodulation positioning patch is applied to a patient's skin. The energy application device is coupled to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. The frame is also coupled to a removable dock for an imaging probe. When the frame is coupled to the removable dock the frame of the neuromodulation positioning patch, acquires image data through the opening to identify or verify the treatment position.

Neuromodulation energy application techniques

Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.

The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.

Patient-specific neuromodulation alignment structures

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

Multi-beam neuromodulation techniques

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Gloversville, NY, United States of America

Jeffrey Michael Ashe