Bristol-myers Squibb Compnay

Eli Lilly and Company

B. Braun Medical Inc.

Jeffrey Manfred Gunnarsson

Mariano Mumpower

Aaron Samuel Pearl

Martin John McLoughlin

Roy Howard Byerly

Benjamin R Lane

Michael Y Brown

Stephen Lawrence Zieminski

Mark David Steenbarger

Collin Grimes

Abbie Lynn Shoemaker

Andre Rafael Minoli

David Earl Hershey, Ii

James Austin Kendall

Samuel Robert Zschack

Christopher Allen Gray

Stephanne Suzann Flint

Alice Maria Weintraut

Jacob Albro Cowperthwaite

Chenrong Meng

Brian P Murphy

Brian Gregory Murphy

Nitin Venkat Vudathala

Collin Hunter Grimes

Martin John Mcloughlin

In one aspect, a combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller having a computing processing unit. Each of the modules includes: a non-transitory memory having stored therein an address and an alphanumeric code representative of the at least one drug component contained in the corresponding drug module; a secondary controller operatively linked to the memory of the corresponding module; and, at least one communication bus connectable in series with the communication buses of the modules serially connected with the corresponding module. The master controller is configured to serially interrogate the secondary controllers over the serially-connected communication buses, using the addresses, to request the codes of the corresponding modules. Advantageously, the subject invention provides for a system to confirm the accuracy of drugs provided with the device and the correct sequencing thereof.

System for interrogating serially-connected drug modules in a combinatorial drug delivery device

Various embodiments are provided herein for checking proper inclusion and sequencing of drug modules in a combinatorial drug delivery device.

Medication error detection system

The present disclosure relates to a dose detection system for use in combination with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system includes a module which is removably attached to the medication delivery device. The module includes a dosing component attached to the actuator during dose delivery. The dosing component includes a light source and a light sensor. A sensed element is attached to the dose setting member and includes surface features detectable by the light sensor.

Medication delivery device

A combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller. Each of the modules includes: a power line; a ground line; a multiplexer having a plurality of identified input channels, at least a subset of the input channels being selectively connected to one of the power and ground lines; a first digital logic line configured to select the input channels; a voltage reference line having a first resistor in line with an output of the multiplexer; a branch line connected to the voltage reference line having a normally closed switch thereon to connect the branch line to the ground line, the switch being opened with connection to a further module. The master controller selects, in sequence, the same identified input channels across all of the modules with measuring a reference voltage thereacross.

System for determining accuracy of serially-connected drug modules in a combinatorial drug delivery device using voltage

An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

Compounding device system, software and method for controlling the process of compounding admixtures

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Bethlehem, PA, United States of America

Jeffrey Manfred Gunnarsson