University of Minnesota

Dow Global Technolgoies LLC

Rohm and Haas Company

Jeffrey M Ting

Frank Steven Bates

Theresa M Reineke

Tushar S Navale

Steven J Guillaudeu

Li Guo

Swapnil Tale

Lakmini Widanapathirana

The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.

Copolymers as excipients for effective solubilization of poorly water-soluble substances from solid mixtures

Disclosed herein are polymers made from at least three monomers of formulae (I), (II), (III), and (IV) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon backbone and are made from monomers that contain at least one carbon-carbon double bond. Methods of making the polymers are also disclosed.

Sugar free, statistical copolymers made from at least three monomers

Disclosed herein are polymers made from at least one monomer of formulae (I), (II), (III), and (IV), in combination with a monomer of formula (V) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon backbone and are made from monomers that contain at least one carbon-carbon double bond. Methods of making these polymers are also disclosed.

Sugar containing, amphiphilic copolymers

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Jeffrey M Ting