The Penn State Research Foundation

University of Michigan

Jeffrey M Sundstrom

Charles D Smith

David A Antonetti

Thomas W Gardner

Lauro V Ojeda

Minghui Huang

Anant Bhamri

Russ Miller

Hakan Demirci

Peter Nguyen

Justin T Holmer

Alan Cruz

A device comprising a syringe comprising a plunger and a barrel having a longitudinal axis and a sample collection volume. The device further comprises a needle hub including an attachment device for connection with the syringe, and a syringe support connected to the needle hub. A needle is connected to the needle hub, the needle having a lumen. An internal needle is at least partially positioned within the lumen of the needle. The device further includes a motor that rotationally moves the internal needle within the needle. The needle has a first opening formed in a side of the needle, and the internal needle has a second opening formed in a side of the internal needle; and wherein material is allowed to enter when the second opening is aligned with the first opening, and wherein the material is cut when the second opening rotates past the first opening.

Devices, systems, and methods for biological sample collection

Methods of treating or preventing a disease or disorder in a subject are provided by the present invention which include administering a composition including a therapeutically effective amount of a protein kinase C (PKC) zeta inhibitor. A disease or disorder treated or prevented by administration of a PKC zeta inhibitor is characterized by abnormal vascular permeability. Diseases or disorders treated or prevented by administration of a composition including a therapeutically effective amount of a PKC zeta inhibitor include cancer, an ischemic condition and microvascular complications of a systemic or local condition in the subject, such as diabetes and/or diabetic macular edema. Additionally, methods of inhibiting PKC zeta are provided which include incubating PKC zeta in vivo, in vitro and/or in silico with a PKC zeta inhibitor.

Protein kinase C zeta inhibition to treat diabetic retinopathy

Protein kinase C zeta inhibition to treat vascular permeability

Growing community of inventors

Hershey, PA, United States of America

Jeffrey M Sundstrom