University System of Maryland

Arizona State University

Northern Arizona University

Jeffrey Leid

Mark E Shirtliff

Timothy L Vail

Janette Harro

Rebecca A Brady

Jennifer M Kofonow

Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment and prevention of Staphylococcus aureus infections in a subject.

Multivalent vaccine protection frominfection

Vaccine formulations effective against, including methicillin-resistant(MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment and prevention ofinfections in a subject.

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The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.

In vivo biofilm infection diagnosis and treatment

The present invention provides methods and kits for biofilm detection.

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Flagstaff, AZ, United States of America

Jeffrey Leid