Fmc Corporation

Miromatrix Medical Inc.

Mayo Foundation for Medical Education and Research

Micromatrix Medical, Inc.

Jeffrey L Ross

Peter J Hatchell

Charles A Sample

James W Krueger

Donald C Crawford

Scott Nyberg

Anne Young

Allie Haarstad

Aleksandr Katane

Steven W Mory

Dominique Seetapun

Blaise Porter

Gary P Strike

Richard S Jenkins

The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.

Use of resected liver serum for whole liver-engineering

The invention provides a method to prepare a graft comprising a recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof, and a method of using the recellularized extracellular matrix of a mammalian liver, liver lobe or portion thereof.

Use of perfusion decellularized liver for islet cell recellularization

The invention provides a method for preparing a perfusion based islet cell containing extracellular matrix of liver, an islet cell recellularized extracellular matrix, and methods of using the recellularized matrix.

A method to provide an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, an inflated decellularized extracellular matrix of a mammalian organ or a vascularized portion thereof, or a mammalian vascularized tissue or a vascularized portion thereof, and uses thereof, are provided.

Gas filled decellularized matrix

The invention provides methods for decellularizing bone, e.g., human bone.

Methods of decellularizing bone

The invention has to do with the modification of well known heat sealing bag machines to increase the production capability of the machines. The use of servo drives for selected components of the bag machine permits the reduction of film acceleration and consequential peak film velocity, thus allowing faster machine cycles at the same film acceleration and consequential film velocity.

Servo driven components of a bag machine

A machine for the continuous production of plastic bags utilizes a servo drive motor to drive the machines film web draw roll assembly and through a seal roll index gear also to drive a seal roll of the machine in coordination with the servo driven draw roll.

Servo drive bag machine

A light contact feeder for receiving randomly spaced articles, lightly abutting the articles and delivering single articles or paired articles to individual flights of a flighted conveyor. A first feeder conveyor lightly abuts articles from a supply conveyor and delivers the abutted articles to a second feeder conveyor which times the articles relative to the flights of the flighted conveyor. A third feeder conveyor matches article speed to flighted conveyor speed and a fourth feeder conveyor phases individual articles for placement between the flights of the flighted conveyor. The fourth conveyor can also group articles in pairs and phase the pairs for placement between the flights of the flighted conveyor.

Computer controlled light contact feeder employing four independently

A machine for the continuous production of plastic bags utilizes a servo drive motor to drive the machines film web draw roll assembly and through a seal roll index gear also to drive a seal roll of the machine in coordination with the servo driven draw roll. Control of the servo motor is through a motion controller receiving inputs form the servo motor.

Servo driven draw roll for bag machine

A non-contact article feeder takes randomly spaced articles and places these articles in proper spacing and timing for transfer to a wrapping machine without the use of tie downs or guide rails. A plurality of flat belt conveyors connected in series open or close gaps between adjacent articles and deliver the articles at proper phase and proper velocity to flights of a conveyor of a wrapping machine. A computer monitors the articles to provide synchronization of individual conveyor belts and between the feeder and the wrapping machine.

Computer controlled non-contact feeder with space-control device

Package wrapping machine infeed conveyor and film web control utilize an infeed conveyor position signal compared to film web signal to adjust the film web letoff to the article in feed conveyor to deliver the article and the film web to a film forming location in register. A processor outputs a digital signal to a motor speed controller which will increase or decrease the feed web letoff rate. Input from the infeed conveyor may be processed by the processor to perform forward or reverse correction as necessary to synchronize the infeed conveyor with the film web letoff.

Master position encoder follower system for film feeding means

A light contact feeder uses a pair of individually controlled conveyor belts to receive randomly spaced articles and to deliver the articles in a lightly abutted arrangement. The feeder uses a trio of accumulator scanners above an accumulator belt to control belt speed and deliver lightly abutted articles to a metering belt. The metering belt delivers the articles at proper speed and phase to an article processing machine.

Computer controlled light contact feeder

The horizontal wrapping machine of the type wherein a succession of articles are fed into a traveling tube of web material which is sealed longitudinally and severed and sealed between the articles to produce individual hermetically sealed packages. A variable speed motor drives a conveyor which may be provided with article feeding flights and a switch, actuated once each revolution of a timing shaft, provides a pulse corresponding to each flight on the article feeding conveyor. In addition an encoder driven by the variable speed drive motor shaft provides a digital velocity signal used as a reference signal for servo motors that may be coupled, in combination or individually, to drive web feed rolls, longitudinal sealing wheels and one or more sealing and severing heads. A delivery conveyor transporting individual packages may, through a suitable drive train, be driven by the variable speed drive motor. The velocity and position of the servo motors is established and controlled through an industrial computer, at a percentage of the velocity of the variable speed drive motor. Thus, the digital velocity and position signal input to the computer by the encoder driven by the variable speed drive motor establishes a reference velocity and position the servo motors.

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Pulaski, WI, United States of America

Jeffrey L Ross