Medefficiency, Inc.

Hansen Pharmaceutical, LLC

Barry University, Inc.

Jeffrey L Jensen

Jodie L Currie

James W Jones

Nathan J Jones

William O Reid, Jr

Christopher C Miller

Daniel Packert

Gerhild Packert

Brian D Gillin

Jason R Hanft

Alex Stenzler

Daniel Robert Jensen

Adam Scott Landsman

Steve Jensen

Frank J McCaney

John V Atanasoff, Ii

Thomas E Gage

Embodiments of the present disclosure provide systems and devices for delivering gaseous Nitric Oxide (gNO) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gNO to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (SSTIs) and osteomyelitis. In some embodiments, the present disclosure provides portable wound healing devices for delivering pressurized gNO to the site of a wound to treat various disease conditions in a subject. Other embodiments relate to systems and devices for delivering and for monitoring gaseous Nitric Oxide (gNO) under therapeutic parameters of use to treat a subject. In certain embodiment, the devices include a subject interface unit comprising sensors for detecting gNO pressure and/or gNO flow.

Gaseous nitric oxide delivery system and methods of use

Headgear includes a base configured to engage the head of the wearer. A force absorbing structure is carried by the base. In some cases, the force absorbing structure includes a surface including a coarse macrostructure configured to facilitate absorbing forces applied to the headgear. The coarse macrostructure includes a plurality of protrusions, and at least one of the protrusions has a thickness of at least about 0.50 mm. In some cases, the force absorbing structure includes a porous macrostructure configured to facilitate absorbing forces applied to the headgear. The porous macrostructure includes a plurality of passageways each having a width of at least about 2.00 mm.

Headgear including force absorbing features

An orthotic device according to embodiments of the present invention includes a substantially rigid internal footbed with an external rocker bottom, two struts rigidly coupled to the footbed, a paddle coupled to each strut, each paddle having an inner surface configured to face a limb of a patient, and a strap system configured to interface with the paddles for tightening around the limb, the inner surfaces of the paddles including a plurality of protrusions configured to minimize sliding of the first and second paddles with respect to the limb or with respect to a cast applied to the limb. The orthotic device may include two or more support layers on the footbed, each layer having a support aperture larger than and at least partially overlapping the support aperture below.

Systems and methods for limb support

Embodiments of the present disclosure provide systems and devices for delivering gaseous Nitrous Oxide (gNO) under therapeutic parameters to reduce infection in a subject. Certain embodiments include devices and systems for delivering pressurized gNO to reduce bioburden and promote healing in the wounds of subjects having various disease conditions, including skin and soft tissue infections (SSTIs) and osteomyelitis. In some embodiments, the present disclosure provides portable wound healing devices for delivering pressurized gNO to the site of a wound to treat various disease conditions in a subject.

Nitric oxide delivery system and methods of use

The present invention provides methods of treatment by delivering nitric oxide at a pressure greater than 1 atmosphere (atm) to a subject in need thereof. Thus, the present invention provides an improved method of treating the skin surface of a subject, and below the skin surface of a subject.

Methods of treatment with nitric oxide at pressures greater than one atmosphere

Embodiments of the present invention provide a system for limb off-weighting, including a sleeve operable to wrap at least partially around a leg, a support strut coupled to the sleeve to receive weight applied to the sleeve, and a foot assembly configured to support and protect the bottom of a foot, wherein the foot assembly is coupled to the support strut and operable to receive weight applied to the sleeve and transfer the weight to underlying surfaces, thus off-weighting and reducing pressure and shearing forces on the foot and ankle. According to some embodiments, foot assembly pivots around the support strut providing an assembled mode and a storage mode. According to other embodiments, sleeve is an open-ended conical shape. According to various other embodiments, the support strut may be tilted to accommodate legs and/or calves of varying sizes, and the foot assembly may adjust to feet of varying sizes.

Systems and methods for off-weighting a limb

Embodiments of the present invention include an apparatus for encouraging compliance with a prescribed orthotic treatment, including an orthotic device applied to a limb of a user, a strap coupled to the orthotic device, the strap having two ends and configured to wrap around the orthotic device at an attachment area, where a length along the strap is smaller than a maximum circumference of the limb distal to the attachment area, and a locking mechanism to lock the strap onto itself. Other embodiments of the present invention include a system for off-weighting a user's foot, including a hardenable cast; a rigid outer boot having a footbed, a first side strut with a first strap aperture, a second side strut with a second strap aperture, and a strap extending through the first strap aperture and the second strap aperture and operable to tighten around the hardenable cast.

Systems and methods for improved off-weighting

An improved apparatus and method for applying a total contact cast to a patient utilizes a kit of pre-packaged materials containing all of the items necessary. A uniquely designed padding strip pads the bony prominence on either side of the ankle, the top metatarsal area, and the crest of the shinbone in one unitary piece. Special cuts in the padding strip allow it to conform tightly to the bend between the foot and lower leg. The special cuts also allow the connected circular or elliptical flaps to also conform easily to the bony prominence of the ankle. Positioning the padding strip is simpler, easier, faster, and provides greater structural integrity to the overall cast. The unitary design helps prevent the padding strip from shifting when the cast is complete. An enlarged base portion of the walking heel eliminates the need for a separate wood platform for support.

Growing community of inventors

Palm City, FL, United States of America

Jeffrey L Jensen