Battelle Memorial Institute

Eli Lilly and Company

Revive Environmental Technology, LLC

Ic Surgical, Inc.

Jeffrey L Ellis

Amy M Heintz

David Arthur Holley

Corrie Bennison

Timothy Mark Blum

Steven Risser

Slawomir Winecki

Darwin Argumedo

Steven Michael Madland

Joshua James

Kavitha Dasu

Christopher Gordon Scheitlin

Joseph Casciano

Aaron Frank

Lindy E Dejarme

Michael M Miller

Doug Hendry

Nathan Bryant

Dan Garbark

William Godwin Atterbury

Thomas D Haubert

John Bartholomew

Christopher Paul McKenzie

Rachel Thurston

John Paul Tallarico

Christopher H Muenzer

Brian J Kaseman

Eric C Scribben

John Tallarico

John D Clay

Chad Edward Bouton

Gaurav Sharma

John P Tallarico

Keith E Brown

Nicholas Annetta

Jeffrey A Friend

George Brand

Andrew Sweeney

Stephanie Kute

Matthew Edward Mowrer

Raymond Richard Zaborski

Keith Brown

Russel R Sirabian

Russell R Sirabian

Beverly Ann Piatt

Christopher P Mckenzie

Alexander Morrow

Jay R Sayre

Lampros Kourtis

Anthony David Duong

Eric Hassenpflug

Mark Lafever

Katherine M Palmer

Michael Scott Ulrich

Beverly Anne Piatt

C Alexander Morrow

Russell Kittel

Kurt Bosworth

Kelly J Jenkins

Michael W Harrison

Rhea Sirkar

Christopher F Buurma

Kevin Yugulis

Sundee Angel

Jeffrey Friend

Michael Funk Chiappetta

Robert Jonathan Cain

Larry K Hooks, Jr

Amy Dindal

Matthew Vaughan

Vince McGinniss

C Byron Tolbert

Tim B Hutson

Krenar Shquau

Steven M Risser

A therapeutic agent delivery system comprises a housing. A therapeutic agent delivery assembly is carried by the housing. The therapeutic agent delivery assembly comprises a chamber having a passageway. A therapeutic agent is carried in the passageway, and a needle is in communication with the passageway. The therapeutic agent delivery assembly may be translatable relative to the housing from a stowed configuration to a deployed configuration. Actuation of a user input may translate the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. An input restraint may be rotatable relative to the housing from a first rotational configuration to a second rotational configuration. In the first rotational configuration the input restraint may inhibit actuation of the user input, and in the second rotational configuration the input restraint may permit actuation of the user input.

Devices and processes for delivery of therapeutic fluids

Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Destruction of PFAS via an oxidation process and apparatus suitable for transportation to contaminated sites

A chemical reaction system is disclosed for use in a device for delivering a therapeutic fluid comprising a liquid base and a polymeric acid. A reaction rate of the chemical reaction system is capable of being adjusted by adjusting at least one of surface area-to-volume ratio, acid concentration, and cross-linking of the polymeric acid.

System for controlling gas generation within a drug delivery device

A device is described in which the shape of a resistive heater material is configured to provide rapid and strong heating of a small area. The resistive heating material is heated unevenly while efficiently using power.

Spot heater

Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.

Processes and devices for delivery of fluid by chemical reaction

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

Processes for delivery of viscous drug therapies

The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Neural sleeve for neuromuscular stimulation, sensing and recording

Devices and systems disclosed herein may include a negative pressure pump that includes a reservoir defining a lumen and a longitudinal axis, a piston, and a drive assembly comprising a spring. Motion of the spring may move the piston along the longitudinal axis of the reservoir to create a negative pressure within the reservoir. Methods of manufacturing a negative pressure pump and using a negative pressure pump to remove fluid from a target site are also described.

Negative pressure pumps and related methods

Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. An exemplary device may include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a one-way valve between the upper chamber and the lower chamber.

Process and device for delivery of fluid by chemical reaction

Processes and devices for delivering a fluid by chemical reaction are disclosed. A chemical reaction is initiated in a reaction chamber to produce a gas, and the gas acts upon a piston to deliver the fluid. Preferred devices typically include an upper chamber, a lower chamber, a fluid chamber, a piston between the lower chamber and the fluid chamber, and a barrier between the upper chamber and the lower chamber. When the barrier is broken, reagents in the upper chamber and the lower chamber are mixed together to generate the gas.

Growing community of inventors

Gahanna, OH, United States of America

Jeffrey L Ellis