Case Western Reserve University

Other

University Radiologists, Inc.

Jeffrey L Duerk

Jonathan S Lewin

Mark A Griswold

Jeffrey L Sunshine

Daniel Robert Elgort

Eddy Y Wong

Hisamoto Moriguchi

Michael Wendt

Jamal J Derakhshan

Claudia M Hillenbrand

Ajit Shankaranarayanan

Candice Bookwalter

Sherif G Nour

Brian M Dale

Chris Flask

Kestutis J Barkauskas

Christopher A Flask

Frank K Wacker

Robbert M Maes

Yiu-Cho Chung

Qiang Zhang

Nicole Seiberlich

John R Haaga

Jinming Gao

Dee H Wu

David Dean

Brent Weinberg

Janardhan K Kamath

Ken Pin Wang

Elmar Merkle

Hua Ai

Ajit Shankaranaravanan

Xintao Shuai

Charlie Yi Wang

Joseph P Molter

David A Miller

Meera S Nair

Dee Hung Wu

Elmar M Merkle

Karan Dara

Gheorghe D Mateescu

Daniel Neumann

A method of diagnosing a mitochondrial related disease in a subject includes administering a deuterated metabolic water precursor to the subject, measuring a rate of deuterated water formation in a sample region of the subject, and comparing the measured deuterated water formation in the sample region to a control value. A difference between the rate of deuterated water formation in the sample region compared to a control value is indicative of a mitochondrial related disease.

Deuterated metabolic water precursor for detecting and treating diseased tissue

Systems, methods, and other embodiments associated with tracking an ablative device and monitoring an ablation produced by the ablative device are described. One example method includes acquiring a magnetic resonance (MR) image of an ablative device inserted in a body and selectively controlling positioning of the ablative device based, at least in part on the MR image. The MR image may be continuously provided in real-time by an interventional MR imaging apparatus programmed to image using a tri-orthogonal plane sequence. The method may also include acquiring an MR image of an ablation performed by the ablative device, and selectively controlling the ablative device based, at least in part, on the MR image. The MR image may also be provided by the IMRI apparatus operating according to a tri-orthogonal plane sequence. In one example, the ablation may treat hypopharyngeal obstructive sleep apnea by reducing tongue base volume.

Magnetic resonance imaging (MRI) guided ablation

Systems, methodologies, media, and other embodiments associated with automatically adapting MRI controlling parameters are described. One exemplary method embodiment includes configuring an MRI apparatus to acquire MR signal data using a non-rectilinear trajectory. The example method may also include acquiring MR signals, transforming the MR signals into image data, and selectively adapting the MRI controlling parameters based, at least in part, on information associated with the MR signals.

Adaptive imaging parameters with MRI

Apparatus, methods, and other embodiments associated with multi-slice blipped TrueFISP-CAIPIRINHA in magnetic resonance imaging (MRI) are described. One example apparatus produces CAIPIRINHA phase cycling in a TrueFISP-CAIPRINHA pulse sequence using a blipped gradient pattern rather than using radio frequency (RF) pulses. The phase cycling is produced by controlling a gradient coil in an MRI apparatus to produce a pre-scan pulse that is configured to set magnetization into a steady state position and then controlling the gradient coil to produce a balanced alternating phase pulse per repetition (TR). The balanced alternating phase pulse is configured to introduce a CAIPIRINHA aliasing pattern between slices. Controlling the gradient coil includes selectively adding and removing a finite gradient area from de-phase pulses and re-phase pulses in the pulse sequence.

Multi-slice blipped TrueFISP-CAIPIRINHA

Apparatus, methods, and other embodiments associated with magnetic resonance imaging (MRI) blipped trajectories having varying blip amplitudes are described. One example method includes controlling an MRI apparatus to produce a set of blipped trajectories including a first blipped trajectory having a first blip amplitude and a second, different blipped trajectory having a second, different blip amplitude. The blip amplitudes may be based on a relationship between a trajectory and a reference. The relationship may be, for example, a rotation angle. The rotation angle may be a proxy for information including a gradient trajectory speed associated with a blipped trajectory or an amount of unused gradient energy available while producing the blipped trajectory. The blip amplitudes may be selected to produce incoherent sampling during an MRI acquisition that uses the blipped trajectories. In one example, readout directions may be altered between trajectories to reduce regularity in k-space.

Varying blipped trajectory in MRI

A new and improved method for tracking and/or spatial localization of an invasive device in Magnetic Resonance Imaging (MRI) is provided. The invention includes providing an invasive device including a marker having a chemically shifted signal source with a resonant frequency different from the chemical species of the subject to be imaged, applying a pulse sequence, detecting the resulting RF magnetic resonance signals, and determining the 3D coordinates of the marker. The invention also includes generating scan planes and reconstructing an image from the detected signals to generate an image having the marker contrasted from the subject. The invasive device includes a marker having a chemically shifted signal source which has a resonant frequency different from the chemical species of the subject to be imaged for use in tracking the device during imaging.

Chemical shift markers for improved wireless fiducial marker tracking

The invention relates to micelles that are elaborated with functionality useful for imaging and/or selectively targeting tissue, e.g., in the delivery of hydrophobic agents.

Dual function polymer micelles

Systems, methods, and other embodiments associated with controlling a magnetic resonance imaging (MRI) apparatus to perform a balanced steady state free precession (bSSFP) technique that includes magnetization preparation with differentiated velocity encoding and spoiling residual transverse magnetization are described. The example systems, methods, and other embodiments are also associated with acquiring a dark blood image in response to the bSSFP technique. A dark blood image is one in which NMR signal acquired from an object subjected to the bSSFP technique and magnetization preparation includes NMR signal from flowing spins and NMR signal from non-flowing spins in a desired ratio.

Dark blood balanced steady state free precession imaging

Example systems and methods control a parallel magnetic resonance imaging (pMRI) apparatus to acquire non-Cartesian (e.g., spiral) calibration data sets throughout time. Example systems and methods also control the pMRI apparatus to acquire an under-sampled non-Cartesian data set from the object to be imaged. Example systems and methods then control the pMRI apparatus to reconstruct an image of the object to be imaged from the under-sampled non-Cartesian data set. The reconstruction depends, at least in part, on a through-time non-Cartesian GRAPPA calibration where a value for a point missing from k-space in the under-sampled non-Cartesian data set is computed using a GRAPPA weight set calibrated and applied for the missing point. The GRAPPA weight set is computed from data in the non-Cartesian calibration data sets.

Through-time non-cartesian grappa calibration

Systems, methods, and other embodiments associated with steady state dark blood magnetic resonance imaging MRI are described. One example method includes controlling an MRI apparatus to produce a steady state pulse sequence. The example method may also include controlling the MRI apparatus to generate radio frequency (RF) energy and magnetic gradients associated with the steady state pulse sequence. The steady state pulse sequence is different from conventional steady state pulses in that it is characterized by regularly spaced slice selection excitation pulses to excite a region to be imaged in an object to be imaged using a consistent repetition time (TR), a set of readout modules, and a set of a magnetization preparation modules. A magnetization preparation module is characterized by gradients associated with imaging not being active, gradients associated with slice selection being active, and RF pulses associated with slice selection being active.

Steady state dark blood magnetic resonance imaging

Systems, methods, and other embodiments associated with RE-TOSSI are described. One system embodiment includes an MRI apparatus configured to produce a RE-TOSSI pulse sequence and to acquire T2-weighted images in response to the RE-TOSSI pulse sequence. An example RE-TOSSI pulse sequence includes a TOSSI portion and a non-inverting, non-TOSSI portion.

Resolution enhanced T1-insensitive steady state imaging (RE-TOSSI)

Systems methods, and other embodiments associated with acquiring intersecting TrueFISP images using grouped reverse centric phase encoding are described. One example method includes controlling an MRI apparatus to produce a TrueFISP sequence that delays acquisition of the center of k-space to reduce saturation banding artifacts. The example method also includes controlling the MRI apparatus to produce a TrueFISP sequence that reduces eddy current artifacts by grouping (e.g., pairing) lines in k-space. The method concludes by acquiring NMR signal in response to the TrueFISP sequence.

Mitigating saturation artifacts associated with intersecting plane TrueFISP acquisitions through grouped reverse centric phase encoding

A method and system for improving image quality by correcting errors introduced by rotational motion of an object being imaged is provided. The object is associated with a fiducial mark. The method provides a computer executable methodology for detecting a rotation and selectively reordering, deleting and/or reacquiring projection data.

Reducing effects of rotational motion

Extended-coverage magnetic resonance imaging coils with optimized homogeneity in longitudinal sensitivity are described. One exemplary coil includes four elements, where two of the elements are opposed-solenoid imaging elements and two of the elements are single loop imaging elements.

Extended-coverage imaging coil

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Avon Lake, OH, United States of America

Jeffrey L Duerk