Flodesign Sonics, Inc.

Jeffrey King

Bart Lipkens

Dane Mealey

Brian McCarthy

Jason Barnes

Walter M Presz, Jr

Kedar C Chitale

Benjamin Ross-Johnsrud

Ben Ross-Johnsrud

Jack Saloio

Thomas J Kennedy, Iii

Brian Dutra

Erik Miller

John Rozembersky

Christopher Jurkiewicz

Richard Grant

Systems and methods for increasing the accuracy of a turbidity sensor are disclosed. The systems include a turbidity sensor and a flow module with a specialized flow path, with the turbidity sensor engaging with the flow module such that a measurement zone of the turbidity sensor is disposed within a flow path of the flow module and a bypass path of the flow module does not pass through the measurement zone. The methods include flowing a fluid containing bubbles into a system that separates the fluid in the flow module into a first stream of fluid containing relatively more bubbles and a second stream of fluid containing relatively fewer bubbles, the first stream flowing through a bypass path that does not pass through the measurement zone, and the second stream flowing through the measurement zone of the turbidity sensor.

Turbidity sensor with improved flow path

Fluidic processing workstation

Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.

Large scale acoustic separation device

Transducer assemblies that can be used in acoustophoretic systems are disclosed. The acoustophoretic systems including the transducer assemblies and methods of operating the acoustophoretic systems are also disclosed. The transducer assemblies include a housing, a polymeric film attached to the housing, and a piezoelectric material attached to the polymeric film. The piezoelectric material is not attached to, and does not come in direct contact with, the housing. The piezoelectric material is configured to be driven by a drive signal to create a multi-dimensional acoustic standing wave. The piezoelectric material can be attached to the polymer film by an adhesive coating on the polymer film.

Piezoelectric transducer for generation of an acoustic standing wave

An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.

Multi-stage acoustophoresis device

Acoustic separation device

Growing community of inventors

Coventry, CT, United States of America

Jeffrey King