The Brigham and Women's Hospital, Inc.

Dana-farber-cancer Institute Inc.

The Charles Stark Draper Laboratory, Inc.

Jeffrey Ishizuka

Matthew Meyerson

William Whitcomb McFarland

William N Haining

Ali Tavakkoli

Robert Manguso

Christopher V Trainor

Daniel F Traviglia

Hugh Gannon

The present invention relates, in part, to methods of treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an agent that inhibits or promotes the copy number, the expression level, and/or the activity of one or more biomarkers listed in Table 1 or a fragment thereof. Also provided herein are methods of detecting ADAR1 or ISG15 dependency in a high proliferation cell (e.g., a cancer cell). Also provided are methods of detected increased interferon signaling pathway activity in a high proliferation cell (e.g., a cancer cell). Included herein are methods of treating cancer with inhibitors of ADAR1 or ISG15. Methods of screening for such inhibitors are also provided herein. Methods of identifying the likelihood of a cancer to be responsive to an ADAR1 inhibitor are also provided.

Modulating dsRNA editing, sensing, and metabolism to increase tumor immunity and improve the efficacy of cancer immunotherapy and/or modulators of intratumoral interferon

The systems and methods described herein related generally to a device that enables the directional control of flow through an anatomical tract of the body. More particularly, the device described herein includes a valve from a plurality of projections. In some implementations, the projections are configured as flaps, posts, or any combination thereof. In some implementations, the device is implanted into a patient's esophagus to prevent gastroesophageal reflux disease. The plurality of projections allow flow into a patient's stomach while substantially preventing a backflow of undesired fluids from the patient's stomach to the patient's esophagus.

Implantable device for directional control of flow within the anatomic tracts of the body

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Boston, MA, United States of America

Jeffrey Ishizuka