Children's Medical Center Corporation

Massachusetts Eye and Ear Infirmary

The Schepens Eye Research Institute, Inc.

Jeffrey Holt

Gwenaelle Geleoc

Luk H Vandenberghe

Konstantina Stankovic

Yukako Asai

Bernard Schneider

Paola Andrea Solanes Vega

Gwenaelle Galeoc

Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect.

Compositions and methods for delivering nucleic acids to cochlear and vestibular cells

Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.

Materials and methods for delivering nucleic acids to cochlear and vestibular cells

Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. Some embodiments are directed to a synthetic inner ear hair cell targeting adeno-associated virus (AAV) vector, a cell comprising the synthetic inner ear hair cell targeting AAV vector, and method of treating Usher Syndrome in a subject using the synthetic inner ear hair cell targeting AAV vector.

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Growing community of inventors

Newton, MA, United States of America

Jeffrey Holt