Intercept Pharmaceuticals, Inc.

Arena Pharmaceuticals, Inc.

Jeffrey Edwards

Kay Olmstead

Mark Pruzanski

Mitsuhiro Matono

Cathi Sciacca

Lise Eliot

Leigh A MacConell

Tonya K Marmon

Richard Gail Lancaster

Richard Pencek

Masashi Kagihiro

Ikuko Taoka

David Shapiro

Roya Hooshmand-Rad

Robert M Jones

Sun Hee Kim

Juerg Lehmann

Weichao George Chen

Abu J M Sadeque

Michael E Morgan

Glen Marquez

Leigh A Macconell

Kay K Olmstead

The present invention relates to the GPR119 receptor agonists: 3-fluoro-4-(5-fluoro-6-(4-3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N,N-imethylbenzamide; 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide; and 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)benzamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single pharmaceutical agent or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPRI19-receptor-related disorder; a condition ameliorated by increasing secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto.

Modulators of the GPR119 receptor and the treatment of disorders related thereto

The disclosure relates to obeticholic acid formulations with improved stability, dissolution, and/or solubility, methods of preparing the same for use and methods of treating various diseases and conditions.

Compositions of obeticholic acid and methods of use

Growing community of inventors

San Diego, CA, United States of America

Jeffrey Edwards