Janssen Pharmaceutica Nv

Leland Stanford Junior University

Abide Therapeutics, Inc.

Lundbeck La Jolla Research Center, Inc.

Siteone Therapeutics, Inc.

Jannsen Pharmaceutica Bv

Jeffrey E Merit

Natalie Anne Hawryluk

J Guy Breitenbucher

John M Keith

Alison L Chambers

Mark S Tichenor

Alec D Lebsack

William Moore Jones

Bryan James Branstetter

Mark Seierstad

Amy K Timmons

Todd Kevin Jones

Cheryl A Grice

Michael D Hack

Olivia Delene Weber

Justin S Cisar

Kelly J McClure

Brett D Allison

Katharine K Duncan

Wei Xiao

Neelakandha S Mani

George P Miljanich

Xiaohu Deng

James Breitenbucher

James Ross Walker

Richard Apodaca

Justin Du Bois

John Mulcahy

Hassan Pajouhesh

Joan M Pierce

Matthew Axtman

Mark J Sierestad

Kelly J Mcclure

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

Pyrazole compounds and methods of making and using same

Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10',11&#x2032;-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10&#x2032;,11&#x2032;-modified saxitoxins are of Formula I: where R, Rand Rare as described herein. Also provided herein are methods of treating pain in a mammal comprising administering an effective treatment amount of a 10&#x2032;,11&#x2032; modified saxitoxin or composition to a mammal. In an embodiment, the mammal is a human. 

10',11&#x2032;-modified saxitoxins useful for the treatment of pain

Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by TRPV1. Thus, the compounds may be administered to treat, e.g., pain, itch, cough, asthma, or inflammatory bowel disease.

Tetrahydro-pyrimidoazepines as modulators of TRPV1

Certain aryl-substituted heterocyclic urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis).

Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).

Heteroaryl-substituted urea modulators of fatty acid amide hydrolase

Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase

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Stanford, CA, United States of America

Jeffrey E Merit