Medtronic, Inc.

Medtronic Vascular, Inc.

Medtronic Cv Luxembourg S.a.r.l.

Medtronic Vascular Galway Limited

Other

Cloc Medical Inc.

Jeffrey D Sandstrom

Joel R Racchini

Paul T Rothstein

Michael Gloss

Patrick Griffin

Niall F Duffy

Kshitija P Garde

James R Keogh

Cynthia T Clague

Jill Mendelson

Jason L Quill

Philip Jon Haarstad

Joshua J Dwork

Declan P Costello

John Gallagher

Marc A Anderson

Finn Olavi Rinne

Michele Lee Silver

Gavin Kenny

Edmond Sheahan

Timothy D Groen

Kate Corish

Frank White

Russell Pribanic

Matthew David Bonner

Kevin M Mauch

Don H Tran

Susheel Deshmukh

Geoffrey Orth

James Calvin Allan

Scott Eric Jahns

Matthew Rust

Igor Kovalsky

Martin Terry Rothman

Roger D Greeley

Steven C Christian

Roderick E Briscoe

Adam Shipley

Evelyn Birmingham

Martha Barajas-Torres

Raymond W Usher

Ana Menk

Padraig Savage

Stephen Nash

Christopher P Olig

Gianfranco Pellegrini

Michael Krivoruchko

Tom P Daigle

Frank Harewood

Michael J Hobday

Steven Claessens

Elizabeth A Schotzko

Phil Haarstad

Marian Creaven

Brian Castelli

Rishi Manda

John Milroy

Michael Bateman

Herinaina Rabarimanantsoa Jamous

David O'Toole

Brendan Vaughan

Stephen Montgomery

Alan McGuinn

Deirdre Bridget McGowan Smyth

Matthew Genovese

Victoria Ung

David Blaeser

Robert Reetz

Vania Lee

Devin Gosal

Alaena Maiorano

Eric Meyer

Thomas Mcpeak

Dermot O'Brien

Katherine S Jolly

Bernard Patrick Mulvihill

Caitlin Dorff

Jeffrey S Voss

William Steinberg

Aashiish Agnihotri

Eric Pierce

Eric Fox

Salvador Avelar

Radhika Bhargav

Dean Christiansen

Paul Rothman

Ana R Buhr

Timothy Groen

Deirdre Mcgowan Smyth

Pradipta K Das

Allan E Dienes

Taylor Winters

Sara Saul

Victor Kimball

Anthony Nesberg

Jorge Zhingre Sanchez

Vijayanarayan Madhavan Potti

Jacob Mchenry

Ryan Stublaski

Delivery devices for delivering a self-expanding prosthetic heart valve are disclosed. The delivery device includes at least one cord is configured to selectively cinch the self-expanding prosthetic heart valve. The delivery device further includes at least one self-expanding release pin comprising a proximal segment, a distal segment, and an intermediate segment positioned between the proximal segment and the distal segment. The at least one self-expanding release pin includes a normal, expanded condition wherein the intermediate segment extends radially outward relative to a central axis of the spindle from the proximal segment to the distal segment. The delivery device further includes a capsule configured to be distally extended relative to the spindle to collapse the at least one self-expanding release pin from the normal, expanded condition of the at least one self-expanding release pin to a collapsed condition of the at least one self-expanding release pin.

Delivery devices for delivering a self-expanding prosthetic heart valve

An implantable medical device system is configured to generate signals and deliver the signals to a heart of a patient. The implantable medical device system includes electronic circuitry configured to deliver cardiac pacing, couplings for an implantable medical lead receptacle, at least some of the couplings electrically connected with the electronic circuitry, a polymeric enclosure having the electronic circuitry contained therein, the polymeric enclosure formed of polymeric material filled around the electronic circuitry and couplings and forming the implantable medical lead receptacle. The implantable medical device may include a first cavity filled with a first material and a second cavity filled with a second material, and the first material is different than the second material.

Polymeric enclosure for implantable medical device

A suture fastener delivery device includes a handle, a fastener delivery end comprising a suture fastener and crimping jaws, and a shaft extending between the handle and the fastener delivery end. The shaft comprises a rail, a plurality of reserve suture fasteners, a side suture slot positioned on a side of the shaft to allow the suture ends to exit the delivery device, and a suture cutting blade adjacent to the rail. The suture fastener delivery device can capture a suture within a side slot of the suture device, and upon activation of a trigger on the handle, crimp and bend the suture fastener to secure the fastener, and cut the excess suture ends via the cutting blade. A slider on the handle can then be used to reload a reserve suture fastener, such that additional fasteners can be deployed without removal of the delivery device from the surgical site.

Suture fastener and delivery device

A transcatheter valve prosthesis including a tubular stent, a prosthetic valve component disposed within and secured to the stent, and a centering mechanism coupled to and encircling an outer surface of the tubular stent. The centering mechanism includes a self-expanding centering ring having an expanded diameter in the expanded configuration that is greater than an expanded diameter of the tubular stent in the expanded configuration and a plurality of self-expanding spokes radially extending between the tubular stent and the centering ring. The centering mechanism may include a base ring and/or a skirt. Alternatively, the centering mechanism includes a plurality of self-expanding loops. When each loop is in a delivery configuration the loop has a straightened profile that proximally extends from a proximal end of the tubular stent. When each loop is in an expanded configuration the loop has a U-shaped profile radially spaced apart from the tubular stent.

Valve prostheses having an integral centering mechanism and methods of use thereof

A system for replacing a heart valve of a patient. The system includes a delivery device and a prosthetic heart valve. The system is configured to be transitionable between a loaded state, a partially deployed state and a deployed state. In the loaded state, the prosthetic heart valve engages a coupling structure and is compressively retained within a primary capsule, which constrains the prosthetic heart valve in a compressed arrangement. In the partially deployed state, the prosthetic heart valve engages the coupling structure and is compressively retained within a secondary capsule, which constrains the prosthetic heart valve to a partially deployed arrangement. The partially deployed arrangement is less compressed than the compressed arrangement and less expanded than a deployed arrangement. In the deployed state, the primary and secondary capsules are retracted from over the prosthetic heart valve, which expands to the deployed arrangement and is released from the coupling structure.

System and method of stepped deployment of prosthetic heart valve

The present disclosure relates to delivery devices for transcatheter stented prosthesis loading, delivery and implantation. The delivery devices provide a loaded delivery state in which the stented prosthesis is loaded and compressed over the delivery device. The compression of the stented prosthesis can be adjusted with one or more elongate tension members, which extend around the stented prosthesis and proximately to an actuation and release assembly that can be provided as part of a handle assembly. The delivery device can be manipulated to adjust tension in the tension members to permit the stented prosthesis to compress, self-expand, and ultimately release from the shaft assembly. In some embodiments, the tension in one or more tension members is adjusted with one or more actuation and release assemblies.

Tension member routing designs to achieve transcatheter stented prosthesis compression

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments. The segments may be orthogonal or oblique to the outer surface of the tubular stent.

Anti-paravalvular leakage component for a transcatheter valve prosthesis

A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Systems, devices and methods for transcatheter valve delivery

Stented prosthetic heart valves comprising a stent frame having a compressed arrangement for delivery within a patient's vasculature and an expanded arrangement for deployment within a native heart valve. The stented prosthetic heart valves including a paravalvular leakage prevention or mitigation wrap that encircles a stent frame and is formed of a flexible material having a variable diameter defined by a greatest distance between the wrap and the stent frame. The wrap further includes a first end coupled to the stent frame and an opposing second end that is not coupled to the stent frame, wherein the wrap can selectively enlarge its diameter in situ via movement of the second end. Devices for and methods of selectively deploying the wrap are also disclosed.

Stented prosthetic heart valve having a wrap and delivery devices

A delivery device for percutaneously delivering a stented prosthetic heart includes a sheath, a handle, and adjustment device including a fine adjustment mechanism, and an outer stability shaft. The sheath defines a lumen and is configured to compressively constrain the stented prosthetic heart valve. The handle is coupled to the proximal portion of the sheath and includes an actuator mechanism coupled to a proximal portion of the sheath that is configured to selectively move the sheath relative to the housing to release the stented prosthetic heat valve. The adjustment device is coupled to the handle and includes an adjustment lumen through which the sheath and the handle slidably extend. The outer stability shaft is coupled to the adjustment device. The fine adjustment mechanism is configured to selectively move the handle and the sheath relative to the adjustment device and the outer stability shaft.

Delivery device for prosthetic heart valve with capsule adjustment device

Methods for rotationally aligning transcatheter heart valve prosthesis within a native heart valve include percutaneously delivering the transcatheter heart valve prosthesis to the native heart valve, wherein the transcatheter heart valve prosthesis includes at least one imaging marker, receiving a cusp overlap viewing angle image and/or a coronary overlap viewing angle image of the transcatheter heart valve prosthesis within the native heart valve, determining, based on the cusp overlap viewing angle image and/or the coronary overlap viewing angle image and the at least one imaging marker, whether the transcatheter heart valve prosthesis is in a desired rotational orientation, if the at least one imaging marker in the cusp overlap viewing angle image and/or the coronary overlap viewing angle indicates that the transcatheter heart valve prosthesis is not in the desired rotational orientation, rotating the transcatheter heart valve prosthesis until the transcatheter heart valve prosthesis is in the desired rotational orientation.

Transcatheter heart valve prosthesis systems and methods for rotational alignment

Aspects of the disclosure relate to devices and methods for preparing an existing, implanted prosthetic aortic valve for subsequent prosthetic aortic valve implantation. To prepare the existing valve, a valve preparation device is delivered to the valve and valve leaflets are severed either via mechanical cutting or electrodes so that the leaflets cannot obstruct a blood flow path once a prosthetic valve is subsequently implanted within the valve. Similarly, in alternate embodiments, devices and methods of the disclosure can be used for preparing a native aortic valve for delivery and implantation of a prosthetic valve.

Devices and methods for aortic valve preparation prior to transcatheter prosthetic valve procedures

Delivery devices for a stented prosthetic heart valve. The delivery device includes a spindle, at least one cord, and a lateral control feature. The cord is tensioned to crimp the prosthesis to a compressed condition for delivery to a target site. Tension is lessened to allow the prosthesis to self-expand. In a tethered and expanded state in which the prosthesis has self-expanded and is connected to the spindle by the cord, the lateral control feature directs the spindle to a prescribed location relative to the prosthesis appropriate for a functional evaluation of the prosthesis. In some embodiments, the spindle is directed to a center of the prosthesis; in other embodiments, the spindle is held at a commissure of the prosthesis. The lateral control features of the present disclosure assume numerous forms.

Transcatheter prosthetic heart valve delivery system with lateral offset control

An integrated valve prosthesis includes an anchor stent, a tether component, and a valve component. The anchor stent includes a self-expanding tubular frame member configured to be deployed in the annulus of an aortic valve or the aorta. The valve component includes a valve frame and a prosthetic valve coupled to the valve frame, and is configured to be deployed within the anchor stent. The tether component includes a first end coupled to the anchor stent and a second end coupled to the valve frame. In the delivery configuration, the tether component extends in a first direction from the anchor stent to the valve component, and in the deployed configuration, the tether component extends in a second direction from the anchor stent to the valve component. The second direction is generally opposite the first direction. The tether component may set the location of the valve component relative to the anchor stent.

Integrated valve assembly and method of delivering and deploying an integrated valve assembly

Growing community of inventors

Scandia, MN, United States of America

Jeffrey D Sandstrom