Amgen Inc.

Jeffrey D Reagan

Julio Cesar Medina

Jonathan B Houze

Liusheng Zhu

Jian Luo

Jiwen Liu

Yingcai Wang

Zhihua Ma

Rajiv Sharma

Michael J Schmitt

Jian Zhang

Jinqian Liu

Stephen J Shuttleworth

Daniel C H Lin

Michelle Akerman

Ying Sun

Wei Qiu

Xiaohui Du

Wang Shen

Ming Yu

Zice Fu

Paul John Dransfield

Sean P Brown

Vatee Pattaropong

Gayathri Swaminath

An-Rong Li

Jie Zhang

Todd J Kohn

Marc Vimolratana

YuMei Xiong

Xian Yun Jiao

Yongli Su

SuJen Lai

Yong-Jae Kim

Margrit Schwarz

Qiong Cao

Li Yang

Daniel Lin

Jinqain Liu

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Substituted biphenyl GPR40 modulators

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

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Woodside, CA, United States of America

Jeffrey D Reagan