Hoechst (uk) Limited

Jeffrey D Michael

Barry C Ross

BIS-Imido carbonate sulphones of the formula: ##STR1## in which R represents phenyl which is unsubstituted or substituted by one or two substituents, which is the same or different, selected from methyl, trifluoromethyl, nitro and cyano groups, and chlorine, flourine and bromine atoms, and p represents the integer 1, are produced by reacting a compound of formula VI ##STR2## in which R is as defined above, with thionyl chloride in the presence of an organic base. The compounds of formula II are useful in the production of 1, 2, 4, 6-thiatriazines.

Bis-imido carbonate sulphones

New thiazole derivatives of the general formula I ##STR1## and their salts with physiologically acceptable acids are described as well as a process for their manufacture. The new compounds exhibit histamine H-2 antagonist activity and may thus be used to inhibit gastric acid secretion and to treat gastric and peptic ulcers.

Growing community of inventors

Milton Keynes, United Kingdom

Jeffrey D Michael