Codexis, Inc.

Jeffrey Colbeck

Benjamin Mijts

Xiyun Zhang

Jack S Liang

John M Gruber

Lisa Marie Newman

Michael D Clay

James Joseph LaLonde

Jagadeesh Mavinahalli

Roger Arthur Sheldon

Sheela Muley

John D Munger, Jr

Jun Zhu

Jian Ding

Vesna Mitchell

Lorraine Joan Giver

Richard John Fox

Lynne Gilson

James LaLonde

Bumshik Robert Pak

Lorraine Jean Giver

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.

Combined automated parallel synthesis of polynucleotide variants

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein.

Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

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Menlo Park, CA, United States of America

Jeffrey Colbeck