Musculoskeletal Transplant Foundation

Jeffrey Cartmell

Moon Hae Sunwoo

Eric Semler

Katherine Gomes Truncale

Yen-Chen Huang

Manh-Dan Ngo

Alison Ling

Kevin Wu

Evangelia Chnari

Mark Spilker

Morris Jacobs

Carina Syring

Rudiger Von Versen

Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.

Methods and compositions for preparing transplant tissue

Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.

The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps:

Soft tissue processing

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Freehold, NJ, United States of America

Jeffrey Cartmell