Archemix Corporation

Baxter International Inc.

Baxter Healthcare Sa

Baxalta Gmbh

Jeffrey C Kurz

Markus Kurz

Charles Wilson

David Epstein

Thomas Greene McCauley

Claude Benedict

James Rottman

Dilara McCauley

John Louis Diener

Kathleen McGinness

Dilara Grate

Robert Schaub

Jennifer Nelson

Ryan Genga

Emily Waters

Kristin Thompson

Sara Chesworth Keene

Anna J Zoltoski

Martin Stanton

Dilârâ McCauley

Nobuko Hamaguchi

Tony Keefe

Kristin A Marshall

Robert G Schaub

The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Aptamer therapeutics useful in the treatment of complement-related disorders

The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI.

Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics

Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder thereapeutics

Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.

Nucleic acid sensor molecules and methods of using same

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Somerville, MA, United States of America

Jeffrey C Kurz